Ülke: Kanada
Dil: İngilizce
Kaynak: Health Canada
CHORIONIC GONADOTROPIN; WATER
EMD SERONO, A DIVISION OF EMD INC., CANADA
G03GA01
CHORIONIC GONADOTROPHIN
10000UNIT; 10ML
KIT
CHORIONIC GONADOTROPIN 10000UNIT; WATER 10ML
INTRAMUSCULAR
SINGLE CARTONS (10000 U)
Prescription
GONADOTROPINS AND ANTIGONADOTROPINS
Active ingredient group (AIG) number: 0223327001; AHFS:
CANCELLED POST MARKET
2007-05-07
022 Control # 040064 Date of Approval: May 5,1997 PACKAGE INSERT Profasi 9 HP chorionic gonadotropin for injection, USP 10,000 USP Units gonadotropin DESCRIPTION Profasi® HP [chorionic gonadotropin for injection, USP (hCG)], extracted from the urine of pregnant women, is a water-soluble polypeptide hormone produced by the human placenta composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha sub-units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH). The beta sub-units of these hormones differ in amino acid sequence. Profasi® HP (chorionic gonadotropin for injection, USP) is biologically standardized and the potency is declared in terms ofthe USP Reference Standard. ACTIONS The action of hCG is virtually identical to that of pituitary LH, although hCG appears to have a small degree of FSH activity as well. Male: Profasi® HP (chorionic gonadotropin for injection, USP) is given in an attempt to stimulate the interstitial cells of the testes (cells of Leydig) to produce androgen. The response to Profasi® HP may be considered similar to the effect produced by the interstitial cell stimulating hormone (ICSH) frpm the anterior lobe of the pituitary. Androgen stimulation in the male leads to^the development of secondary sex characteristics and may stimulate testicular descent when no anatomical impediment to descent is present. This descent is usually reversible when hCG is discontinued. Profasi® HP is likely to be of benefit in all conditions directly related to insufficient secretion of androgen, provided the interstitial cells of the testes are capable of stimulation. Female: Profasi® HP is administered in the second phase of the cycle in an attempt to maintain the functional integrity of the corpus luteum and to stimulate its secretion of progesterone. Response to Profasi® HP may be considered similar to the effect produced by the luteotro Belgenin tamamını okuyun