PHENYLBUTE- phenylbutazone injection

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

PHENYLBUTAZONE (UNII: GN5P7K3T8S) (PHENYLBUTAZONE - UNII:GN5P7K3T8S)

Mevcut itibaren:

Clipper Distributing Company, LLC

INN (International Adı):

PHENYLBUTAZONE

Kompozisyon:

PHENYLBUTAZONE 200 mg in 1 mL

Uygulama yolu:

INTRAVENOUS

Reçete türü:

PRESCRIPTION

Terapötik endikasyonlar:

For relief of inflammatory conditions associated with the musculoskeletal system in horses. Treated animals should not be slaughtered for food purposes. Parenteral injections should be made intravenously only; do not inject subcutaneously or intramuscularly. Use with caution in patients who have a history of drug allergy. For relief of inflammatory conditions associated with the musculoskeletal system in horses. Intravenous dosage (not subcutaneous or intramuscular use) : Horses : 1 to 2 g per 1,000 lb body weight (5 to 10 mL/1,000 lb) daily. Not for use in Horses intended for food. See package outsert for additional information. ANADA 200-371, Approved by FDA Each mL contains: Phenylbutazone ............................. 200 mg Benzyl Alcohol Preservative .........10.45 mg Sodium hydroxide to adjust pH to 9.5 to 10.0 Water For Injection ...............................q.s.

Ürün özeti:

INJECTABLE : For Horses only: 100 mL vials, 200 mg/mL (1 g/5 mL) Each mL contians 200 mg of phenylbutazone, 10.45 mg of benzyl alcohol as preservative, sodium hydroxide to adjust pH to 9.5 to 10.0, and water for injection, Q.S.

Yetkilendirme durumu:

Abbreviated New Animal Drug Application

Ürün özellikleri

PHENYLBUTE - PHENYLBUTAZONE INJECTION
CLIPPER DISTRIBUTING COMPANY, LLC
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PHENYLBUTE® INJECTION 20% (PHENYLBUTAZONE)
FOR HORSES ONLY
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed veterinarian.
DESCRIPTION: Phenylbutazone 20% Injection (phenylbutazone) is a
synthetic, nonhormonal anti-
inflammatory, antipyretic compound useful in the management of
inflammatory conditions. The apparent
analgesic effect is probably related mainly to the compound's
anti-inflammatory properties. Chemically,
phenylbutazone is 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione. It is a
pyrazolon derivative entirely
unrelated to the steroid hormones, and has the following structural
formula:
BACKGROUND PHARMACOLOGY
Kuzell,
Payne,
Fleming,
and Denko demonstrated clinical effectiveness of phenylbutazone in
acute rheumatism, gout, gouty arthritis and various other rheumatoid
disorders in man. Anti-rheumatic
and anti-inflammatory activity has been well established by Fabre,
Domenjoz,
Wilhelmi,
and
Yourish.
Lieberman
reported on the effective use of phenylbutazone in the treatment of
painful
conditions of the musculosketal system in dogs; including posterior
paralysis associated with
intervertebral disc syndrome, painful fractures, arthritis, and
painful injuries to the limbs and joints.
Joshua
observed objective improvement without toxicity following long-term
therapy of two aged
arthritic dogs. Ogilvie and Sutter
reported rapid response to phenylbutazone therapy in a review of 19
clinical cases including posterior paralysis, posterior weakness,
arthritis, rheumatism, and other
conditions associated with lameness and musculoskeletal weakness.
Camberos
reported favorable results with phenylbutazone following intermittent
treatment of
Thoroughbred horses for arthritis and chronic arthrosis (e.g.,
osteoarthritis of medial and distal bones
of the hock, arthritis of stifle and hip, arthrosis of the spine,
chronic hip pains, achronic pain in the
trapezius muscles, and generalized arthritis). Results were less
f