Lamotrigine-GA

Ülke: Avustralya

Dil: İngilizce

Kaynak: Department of Health (Therapeutic Goods Administration)

Aktif bileşen:

Lamotrigine

Mevcut itibaren:

Actavis Pty Ltd

Sınıf:

Medicine Registered

Bilgilendirme broşürü

 
LAMOTRIGINE-GA 
CONSUMER MEDICINE INFORMATION 
_Lamotrigine dispersible/chewable tablets _
_ _
WHAT IS IN THIS LEAFLET 

Please read this leaflet carefully 
before you take LAMOTRIGINE-GA 
tablets. 

This leaflet answers some common 
questions about LAMOTRIGINE-
GA. It does not contain all the 
available information. 

It does not take the place of talking 
to your doctor and pharmacist. 

All medicines have risks and 
benefits. Sometimes new risks are 
found even when a medicine has 
been used for many years. Your 
doctor has weighed the risks of you 
taking LAMOTRIGINE-GA against 
the benefits this medicine is 
expected to have for you. 

IF YOU HAVE ANY CONCERNS ABOUT 
TAKING THIS MEDICINE, ASK YOUR 
DOCTOR OR PHARMACIST. 

KEEP THIS LEAFLET WITH THE 
MEDICINE. You may need to read it 
again. 

WHAT LAMOTRIGINE-GA IS 
USED FOR 

LAMOTRIGINE-GA contains the 
active ingredient lamotrigine and is 
an antiepileptic drug used to treat 
epilepsy in adults and children. 

Epilepsy is caused by a disruption in 
the electrical activity of the brain.  

The abnormal electrical impulses 
occur due to altered levels of some 
of the chemicals in the brain.  

LAMOTRIGINE-GA tablets work by 
altering the levels of some of the 
chemicals causing the seizures.  

LAMOTRIGINE-GA is used in partial 
seizures that affect only one part of 
the brain or generalised seizures 
that affect the whole brain including 
Lennox-Gastaut Syndrome.  

Lennox-Gastaut Syndrome (LGS) is 
a severe form of epilepsy and is 
characterised by several seizure 
types. 

LAMOTRIGINE-GA tablets are 
initially used in addition to other 
medicines for the treatment of 
epilepsy.  

Your doctor may have prescribed 
LAMOTRIGINE-GA for another 
reason. Ask your doctor if you have 
any questions about why 
LAMOTRIGINE-GA has been 
prescribed for you. 

This medicine is available only with 
a doctor’s prescription. 

There is no evidence that 
LAMOTRIGIN

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Lamotrigine-GA PI  V5 
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LAMOTRIGINE-GA 
PRODUCT INFORMATION  

Severe,  potentially  life-threatening  rashes  have  been  reported  in  association  with  the  use  of 
lamotrigine, particularly in children. Accordingly, lamotrigine should be discontinued at  the first 
sign of rash unless the rash is clearly not drug
related. (see DOSAGE AND ADMINISTRATION). 

NAME OF THE MEDICINE 
Lamotrigine 
Chemical name for lamotrigine is 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine 

CAS No.: 84057-84-1  

Molecular formula: C
9
H
7
Cl
2
N
5

           MW: 256.1  

DESCRIPTION  
Lamotrigine is a substituted asymmetric triazine. It is a white to pale cream coloured powder. It 
is  slightly  soluble  in  ethanol  and  chloroform,  and  very  slightly  soluble  in  water.  The  pKa  of 
lamotrigine at 25°C is 5.7.  

Each  tablet  contains:  Calcium  carbonate,  sorbitol,  cellulose-microcrystalline,  crospovidone, 
starch-maize, purified talc, saccharin sodium, sodium stearylfumarate, colloidal anhydrous silica 
and blackcurrant flavour.  

PHARMACOLOGY  
Lamotrigine  is  an  anticonvulsant  and  its  action  is  uncertain.  The  results of  neurochemical  and 
electrophysiological  studies  with  various  _in  vitro_  and  _in  vivo_  preparations  indicate  that 
lamotrigine can inhibit voltage gated sodium channels and reduce the release of glutamate, an 
excitatory  amino  acid  implicated  in  the  pathophysiology  of  epilepsy.  It  is  possible  that  these 
effects  underlie  inhibition  of  the  sustained  repetitive  firing  of  action  potentials  characteristic  of 
neurones in epileptic foci, thereby limiting the spread
of seizures.  

In tests designed to evaluate the ce