Ülke: Yeni Zelanda
Dil: İngilizce
Kaynak: Medsafe (Medicines Safety Authority)
Cefoxitin sodium 1.051 g equivalent to cefoxitin 1 g
Pfizer New Zealand Limited
Cefoxitin sodium 1.051 g (= cefoxitin 1 g)
1 g
Powder for injection
Active: Cefoxitin sodium 1.051 g equivalent to cefoxitin 1 g
Vial, glass, single dose, molded, Type I, clear, 20 mL, with a grey closure, Al seal & PP plastic button; 5x1g vials, 5 g
Prescription
Prescription
Orchid Chemicals and Pharmaceuticals Limited
Hospira™ Cefoxitin Sodium Powder for Injection is indicated for the treatment of the following infections when due to susceptible organisms (see Microbiology) peritonitis and other intraabdominal and intra-pelvic infections, female genital tract infections, septicaemia, endocarditis, urinary tract infections, respiratory tract infections, bone and joint infections, skin and skin structure infections. Hospira™ Cefoxitin Sodium Powder for Injection has a high degree of stability against betalactamase and is therefore effective against beta-lactamase producing organisms resistant to penicillins or cephalosporins. It can also be used in mixed infections provided that the organisms are sensitive to it. Hospira™ Cefoxitin Sodium Powder for Injection can be used as adjunctive therapy in the surgical treatment of infections including abscesses, infection complicating hollow viscous perforations, cutaneous infections and infections of serous surfaces whether caused by aerobes, mixed aerobes and anaerobes, or anaerobes.
Package - Contents - Shelf Life: Vial, glass, single dose, molded, Type I, clear, 20 mL, with a grey closure, Al seal & PP plastic button; 5x1g vials - 5 g - 24 months from date of manufacture stored at or below 25°C protect from light 24 hours reconstituted stored at 2° to 8°C (Refrigerate, do not freeze) protect from light
2011-11-21
Datasheet – New Zealand Version 2.0 Page 1 HOSPIRA™ CEFOXITIN SODIUM POWDER FOR INJECTION NAME OF THE MEDICINE Non proprietary name: cefoxitin sodium Chemical name: Sodium (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[[(thiophen-2- yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Molecular formula: C 16 H 16 N 3 NaO 7 S 2 Molecular weight: 449.4 Chemical Abstracts Service (CAS) registry number: 33564-30-6 DESCRIPTION Hospira™ Cefoxitin Sodium Powder for Injection is a white to off white sterile powder of cefoxitin sodium for intravenous and intramuscular administration following reconstitution. Each vial contains cefoxitin sodium equivalent to 1 g of Cefoxitin. Each gram of cefoxitin sodium contains approximately 51.2 mg (2.2 mEq) of sodium. The pH of 10% w/v cefoxitin sodium in Water for Injections is 4.2 to 7.0. PHARMACOLOGY Cefoxitin is a bactericidal antibiotic which acts by inhibiting bacterial cell wall synthesis. Due to the presence of a 7- methoxy group in the -lactam ring, it exhibits a high degree of stability in the presence of beta-lactamases. MICROBIOLOGY Cefoxitin is active against the following microorganisms _in vitro_: Aerobic bacteria 1. Gram-positive cocci including _Staphylococci_ (including coagulase-positive, coagulase- negative and penicillinase producing strains), Group A beta-haemolytic streptococci (_Streptococcus pyogenes_), Group B beta-haemolytic streptococci (_Streptococcus agalactiae_) and Streptococcus pneumoniae (_Diplococcus pneumoniae_). Other streptococci (most strains of enterococci, e.g. _Streptococcus faecalis_) are resistant. 2. Gram-negative cocci including _Neisseria gonorrhoeae_ (including penicillinase-producing strains) and _Neisseria meningitidis_. 3. Gram-negative rods (facultative anaerobes) including _Escherichia coli, Klebsiella _ _pneumoniae, Klebsiella_ spp, _Proteus mirabilis, Proteus _(indole-positive), _Proteus vulgaris, _ _Providencia rettgeri, Morganella morganii, Serratia marcescens , Providencia_ spp, _Salmonella_ an Belgenin tamamını okuyun