Ülke: Yeni Zelanda
Dil: İngilizce
Kaynak: Medsafe (Medicines Safety Authority)
Latanoprost 0.05mg
Douglas Pharmaceuticals Limited
Latanoprost 0.05 mg
50 mcg/mL
Eye drops, solution
Active: Latanoprost 0.05mg Excipient: Benzalkonium chloride Dibasic sodium phosphate Monobasic sodium phosphate monohydrate Purified water Sodium chloride
Bottle, dropper, LDPE with HDPE cap, 2.5 mL
Prescription
Prescription
Everlight Chemical Industrial Corporation
Reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Package - Contents - Shelf Life: Bottle, dropper, LDPE with HDPE cap - 2.5 mL - 24 months from date of manufacture stored at 2° to 8°C (Refrigerate, do not freeze) protect from light 4 weeks opened stored at or below 25°C protect from light
2010-07-12
DATASHEET EYEPROST ® , EYE DROPS _(LATANOPROST 50 MICROGRAMS/ML) _ NAME OF THE DRUG latanoprost The chemical name of latanoprost is Isopropyl-(Z)-7[(1R,2R,3R,5S) 3,5-dihydroxy-2-[(3R)- 3-hydroxy-5-phenyl-1-pentyl]cyclopentyl]-5-heptenoate, according to IUPAC. DESCRIPTION The active ingredient in EYEPROST is latanoprost, a prostaglandin F 2α analogue. Latanoprost is a viscous oil which is practically insoluble in water, freely soluble in ethanol, ethyl acetate, isopropanol, methanol, acetone and octanol, and very soluble in acetonitrile. Sixty four isomers of latanoprost are possible, however, for EYEPROST it is purified as a single isomer. EYEPROST Eye Drops is a sterile, isotonic solution containing 50 micrograms/mL of latanoprost in an aqueous buffer solution of pH 6.7. The excipients in EYEPROST are sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate anhydrous, water for injections and benzalkonium chloride (0.20mg/mL) as a preservative agent. PHARMACOLOGY _PHARMACOKINETICS _ Latanoprost is an isopropyl ester pro drug which is inactive, but after hydrolysis to the acid of latanoprost, becomes biologically active. The pro drug is well absorbed through the cornea and all drug that enters the aqueous humour is hydrolysed during the passage through the cornea. Studies in man indicate that the peak concentration in the aqueous humour is reached about two hours after topical administration. After topical application in monkeys latanoprost is distributed primarily in the anterior segment, the conjunctivae and the eye lids. Only minute quantities of the drug reach the posterior segment. Following an ocular dose of latanoprost, 45% of latanop Belgenin tamamını okuyun