EPINEPHRINE injection

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

EPINEPHRINE (UNII: YKH834O4BH) (EPINEPHRINE - UNII:YKH834O4BH)

Mevcut itibaren:

HF Acquisition Co LLC, DBA HealthFirst

Uygulama yolu:

INTRACARDIAC

Reçete türü:

PRESCRIPTION DRUG

Terapötik endikasyonlar:

EPINEPHRINE Epinephrine’s cardiac effects may be of use in the treatment and prophylaxis of cardiac arrest due to various causes in the absence of ventricular fibrillation and attacks of transitory atrioventricular (AV) heart block with syncopal seizures (Stokes-Adams syndrome), but it is not used in cardiac failure or in hemorrhagic, traumatic or in cardiogenic shock. Epinephrine may be used to stimulate the heart in syncope due to complete heart block or carotid sinus hypersensitivity. Epinephrine is also used for resuscitation in cardiac arrest following anesthetic accidents. In cardiopulmonary resuscitation, intracardiac puncture and intramyocardial injection of epinephrine may be effective when external cardiac compression and attempts to restore the circulation by electrical defibillation or use of a pacemaker fail. Epinephrine is seldom used as a vasopressor except in the treatment of anaphylactic shock and under certain conditions in insulin shock. Epinephrine should not be used in the presence of car

Ürün özeti:

EPINEPHRINE is supplied in the following dosage forms. NDC 51662-1381-1 EPINEPHRINE INJ. USP, 0.1 mg/mL 1mg per 10mL LUER-JET™ SYR HF Acquisition Co LLC, DBA HealthFirst Mukilteo, WA 98275 Also supplied in the following manufacture supplied dosage forms

Yetkilendirme durumu:

unapproved drug other

Ürün özellikleri

EPINEPHRINE- EPINEPHRINE INJECTION
HF ACQUISITION CO LLC, DBA HEALTHFIRST
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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EPINEPHRINE INJ. USP, 0.1 MG/ML 1MG PER 10ML LUER-JET™ SYR
SPL UNCLASSIFIED
EPINEPHRINE INJECTION, USP
AVAILABLE AS:
EPINEPHRINE INJECTION, USP, 0.1 mg/mL
FOR INTRACARDIAC OR
INTRAVENOUS USE
DESCRIPTION
Epinephrine is the active principle of the adrenal medulla. Chemically
described as (-)-3,4-Dihydroxy-
α-[(methyl-amino) methyl] benzyl alcohol, it has the following
structural formula:
Epinephrine is a sterile aqueous solution of epinephrine prepared with
the aid of hydrochloric acid.
Each mL of the solution contains 0.1 mg epinephrine and 1 mg sodium
bisulfite. Sodium bisulfite is an
antioxidant. This solution also contains sodium chloride for
adjustment of tonicity, and 10% w/v
hydrochloric acid to dissolve epinephrine and to adjust pH to meet USP
limits of 2.2 to 5.0.
Additionally, the solution also contains sodium citrate and citric
acid as buffers for stabilization. The
air above the liquid in the individual containers have been displaced
by flushing with nitrogen during the
filling operation. No antimicrobial preservatives have been added and
each vial is intended as a single
dose; once the unit is assembled and used, any remaining portion of
the solution must be discarded with
the entire unit.
CLINIAL PHARMACOLOGY
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. To a variable
degree, it acts on both alpha and beta receptor sites of sympathetic
effector cells. Its most prominent
actions are on the beta receptors of the heart, vascular and other
smooth muscle. When given by rapid
I.V. injection it produces a rapid rise in blood pressure, mainly
systolic, direct stimulation of cardiac
muscle which increases the strength of ventricular contraction,
increases the heart rate, and constricts
the arterioles in