EPINEPHRINE injection

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

EPINEPHRINE (UNII: YKH834O4BH) (EPINEPHRINE - UNII:YKH834O4BH)

Mevcut itibaren:

REMEDYREPACK INC.

Uygulama yolu:

INTRAVENOUS

Reçete türü:

PRESCRIPTION DRUG

Terapötik endikasyonlar:

EPINEPHRINE Epinephrine’s cardiac effects may be of use in the treatment and prophylaxis of cardiac arrest due to various causes in the absence of ventricular fibrillation and attacks of transitory atrioventricular (AV) heart block with syncopal seizures (Stokes-Adams syndrome), but it is not used in cardiac failure or in hemorrhagic, traumatic or in cardiogenic shock. Epinephrine may be used to stimulate the heart in syncope due to complete heart block or carotid sinus hypersensitivity. Epinephrine is also used for resuscitation in cardiac arrest following anesthetic accidents. In cardiopulmonary resuscitation, intracardiac puncture and intramyocardial injection of epinephrine may be effective when external cardiac compression and attempts to restore the circulation by electrical defibillation or use of a pacemaker fail. Epinephrine is seldom used as a vasopressor except in the treatment of anaphylactic shock and under certain conditions in insulin shock. Epinephrine should not be used in the presence of cardiac dilatation or coronary insufficiency. Epinephrine is contraindicated in shock during general anesthesia with halogenated hydrocarbons or cyclopropane, and in individuals with organic brain damage. Epinephrine is also contraindicated with local anesthesia of certain areas; e.g., fingers, toes, because of the danger of vasoconstriction producing sloughing of tissue; also contraindicated in labor because it may delay the second stage. Epinephrine should not be used in those cases where vasopressor drugs may be contraindicated, e.g., in thyrotoxicosis, diabetes, in obstetrics when maternal blood pressure is in excess of 130/80, and in hypertension and other cardiovascular disorders.

Ürün özeti:

EPINEPHRINE INJECTION, USP, 0.1 mg/ mL In unit-use packages containing a Luer-Jet™ Luer-Lock Prefilled Syringe NDC: 70518-2781-00 PACKAGING: 10 in 1 PACKAGING, 10 mL in 1 VIAL, TYPE 2 *CAUTION: IMPROPER ENGAGING MAY CAUSE GLASS BREAKAGE AND SUBSEQUENT INJURY. Protect the solution from light, extreme heat and freezing. Store at controlled room temperature 15˚ to 30˚C (59˚ to 86˚F). NOTE: Do not use the injection if its color is pinkish or darker than slightly yellow or if it contains a precipitate. Rx Only Repackaged and Distributed By: Remedy Repack, Inc. 625 Kolter Dr. Suite #4 Indiana, PA 1-724-465-8762

Yetkilendirme durumu:

unapproved drug other

Ürün özellikleri

EPINEPHRINE- EPINEPHRINE INJECTION
REMEDYREPACK INC.
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
----------
EPINEPHRINE INJECTION, USP
AVAILABLE AS:
EPINEPHRINE INJECTION, USP, 0.1 MG/ML
FOR INTRACARDIAC OR
INTRAVENOUS USE
DESCRIPTION
Epinephrine is the active principle of the adrenal medulla. Chemically
described as (-)-3,4-
Dihydroxy-α-[(methyl-amino) methyl] benzyl alcohol, it has the
following structural
formula:
Epinephrine is a sterile aqueous solution of epinephrine prepared with
the aid of
hydrochloric acid. Each mL of the solution contains 0.1 mg epinephrine
and 1 mg
sodium bisulfite. Sodium bisulfite is an antioxidant. This solution
also contains sodium
chloride for adjustment of tonicity, and 10% w/v hydrochloric acid to
dissolve
epinephrine and to adjust pH to meet USP limits of 2.2 to 5.0.
Additionally, the solution
also contains sodium citrate and citric acid as buffers for
stabilization. The air above the
liquid in the individual containers have been displaced by flushing
with nitrogen during
the filling operation. No antimicrobial preservatives have been added
and each vial is
intended as a single dose; once the unit is assembled and used, any
remaining portion of
the solution must be discarded with the entire unit.
CLINICAL PHARMACOLOGY
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. To a
variable degree, it acts on both alpha and beta receptor sites of
sympathetic effector
cells. Its most prominent actions are on the beta receptors of the
heart, vascular and
other smooth muscle. When given by rapid I.V. injection it produces a
rapid rise in blood
pressure, mainly systolic, direct stimulation of cardiac muscle which
increases the
strength of ventricular contraction, increases the heart rate, and
constricts the
arterioles in the skin, mucosa and splanchnic areas of circulation.
Epinephrine relaxes the smooth muscle of