ENFLURANE LIQUID

Ülke: Kanada

Dil: İngilizce

Kaynak: Health Canada

Aktif bileşen:

ENFLURANE

Mevcut itibaren:

ABBVIE CORPORATION

ATC kodu:

N01AB04

INN (International Adı):

ENFLURANE

Doz:

99.9%

Farmasötik formu:

LIQUID

Kompozisyon:

ENFLURANE 99.9%

Uygulama yolu:

INHALATION

Paketteki üniteler:

250ML

Reçete türü:

Prescription

Terapötik alanı:

INHALATION ANESTHETICS

Ürün özeti:

Active ingredient group (AIG) number: 0109479001; AHFS:

Yetkilendirme durumu:

CANCELLED POST MARKET

Yetkilendirme tarihi:

2012-11-02

Ürün özellikleri

Prescribing Information
ENFLURANE

(enflurane)
Inhalation Anesthetic
AbbVie Corporation
DATE OF PREPARATION:
8401 Trans Canada Highway
November 1, 2012
Saint-Laurent (Qc) Canada H4S lZ1
DATE OF PREVIOUS REVISION:
Control # 158312
DATE OF REVISION:
- 2 -
NAME OF DRUG
ENFLURANE

(enflurane)
THERAPEUTIC CLASSIFICATION
Inhalation Anesthetic
ACTIONS AND CLINICAL PHARMACOLOGY
ENFLURANE

(enflurane),
a
halogenated
methylethyl
ether,
is
an
inhalation
anesthetic.
Induction and recovery from ENFLURANE

anesthesia are rapid. ENFLURANE

does not
appear to stimulate excessive salivation or tracheo-bronchial
secretions, or affect bronchomotor
tone. Pharyngeal and laryngeal reflexes are readily obtunded. The
level of anesthesia can be
changed rapidly by changing the inspired ENFLURANE

concentration. This property would be
predicted based upon its Oswald partition coefficients.
ENFLURANE

reduces ventilation as depth of anesthesia increases. This is a result
of a
decrease in tidal volume with rate of respiration remaining
essentially constant. ENFLURANE

provokes a sigh response reminiscent of diethyl ether.
There is a decrease in blood pressure with induction of anesthesia,
followed by a return to near
normal with surgical stimulation. A slight fall in cardiac output,
stroke volume, and peripheral
resistance, and an increase in central venous pressure may occur.
Progressive increases in
depth of anesthesia produce corresponding increases in hypotension.
Electrocardiographic
monitoring and recording indicate that the cardiac rhythm remains
remarkably stable. Elevation
of carbon dioxide level in arterial blood does not alter cardiac
rhythm.
ENFLURANE

has been shown to sensitize the myocardial conduction system to
epinephrine,
and serious arrhythmias including ventricular fibrillation have
occurred in dogs.
However, studies in human subjects indicate that there is a certain
margin of safety in the
administration
of
epinephrine-containing
solutions
during
ENFLURANE

anesthesia.
ENFLURANE

anesthes