DRY-CLOX- cloxacillin benzathine gel

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

CLOXACILLIN BENZATHINE (UNII: AC79L7PV2G) (CLOXACILLIN - UNII:O6X5QGC2VB)

Mevcut itibaren:

Boehringer Ingelheim Animal Health USA Inc.

INN (International Adı):

CLOXACILLIN BENZATHINE

Kompozisyon:

CLOXACILLIN 500 mg in 10 mL

Uygulama yolu:

INTRAMAMMARY

Reçete türü:

PRESCRIPTION

Terapötik endikasyonlar:

For the treatment of mastitis in dairy cows during the dry period. DRY-CLOX has been shown by extensive clinical studies to be efficacious in the treatment of mastitis in dry cows, when caused by Streptococcus agalactiae and Staphylococcus aureus including penicillin-resistant strains. Treatment of the dry cow with DRY-CLOX is indicated in any cow known to harbor any of these organisms in the udder at drying off, or which has had repeated attacks of mastitis during the previous lactation, or is affected with mastitis at drying off, if caused by susceptible organisms.

Ürün özeti:

DRY-CLOX (cloxacillin benzathine) is supplied as 10 mL syringes containing 500 mg of cloxacillin activity per syringe. One display carton contains 12 syringes. One pail contains 144 syringes. NDC 0010-4720-02 - 12 syringes NDC 0010-4720-03 - 144 syringes

Yetkilendirme durumu:

New Animal Drug Application

Ürün özellikleri

DRY-CLOX- CLOXACILLIN BENZATHINE GEL
BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
----------
DRY-CLOX
(CLOXACILLIN BENZATHINE)
INTRAMAMMARY INFUSION
FOR USE IN DRY COW ONLY
Approved by FDA under NADA # 055-058
CAUTION:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION:
DRY-CLOX (cloxacillin benzathine) is a product which provides
bactericidal activity
against gram-positive bacteria in the dry cow. The active agent,
cloxacillin benzathine, is
a sparingly soluble salt of the semisynthetic penicillin, cloxacillin.
Cloxacillin is a derivative
of 6-aminopenicillanic acid, and therefore is chemically related to
other penicillins. It has,
however, the antibacterial properties described below, which
distinguish it from certain
other penicillins.
Each 10 mL disposable syringe contains cloxacillin benzathine
equivalent to 500 mg of
cloxacillin activity in a stable peanut oil gel. This product was
manufactured by a non-
sterilizing process.
STORAGE:
Do not store above 25°C (77°F). Do not freeze.
ACTION:
In the non-lactating mammary gland, DRY-CLOX provides bactericidal
levels of the active
antibiotic, cloxacillin, for a prolonged period of time. This
prolonged activity is due to the
low solubility of the cloxacillin benzathine and to the slow-release
oil-gel base. This
prolonged contact between the antibiotic and the pathogenic organism
enhances the
probability of a bacteriological cure.
Cloxacillin is not destroyed by the enzyme, penicillinase, and
therefore, is active against
penicillin-resistant strains of _Staphylococcus aureus_. It is also
active against non-
penicillinase-producing _Staphylococcus aureus_ as well as
_Streptococcus agalactiae_.
The class disc, Methicillin 5 mcg, should be used to estimate the _in
vitro_ susceptibility of
bacteria to cloxacillin.
INDICATIONS:
®
For the treatment of mastitis in dairy cows during the dry period.
DRY-CLOX has been shown by extensive clinical studies to be
efficacious in the
treatment of mastitis in dry cows, when caused by