DOXAZOSIN tablet

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

DOXAZOSIN MESYLATE (UNII: 86P6PQK0MU) (DOXAZOSIN - UNII:NW1291F1W8)

Mevcut itibaren:

St Marys Medical Park Pharmacy

INN (International Adı):

DOXAZOSIN MESYLATE

Kompozisyon:

DOXAZOSIN 2 mg

Reçete türü:

PRESCRIPTION DRUG

Yetkilendirme durumu:

Abbreviated New Drug Application

Ürün özellikleri

DOXAZOSIN - DOXAZOSIN TABLET
ST MARYS MEDICAL PARK PHARMACY
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DOXAZOSIN TABLETS, USP
1 MG, 2 MG, 4 MG AND 8 MG
RX ONLY
DESCRIPTION
Doxazosin mesylate is a quinazoline compound that is a selective
inhibitor of the alpha subtype of
alpha-adrenergic receptors. The chemical name of doxazosin mesylate is
1-(4-amino-6,7- dimethoxy-2-
quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine
methanesulfonate. The empirical formula
for doxazosin mesylate is C
H N O • CH O S and the molecular weight is 547.6. It has the
following structure:
Doxazosin mesylate is freely soluble in dimethylsulfoxide, soluble in
dimethylformamide, slightly
soluble in methanol, ethanol, and water (0.8% at 25°C), and very
slightly soluble in acetone and
methylene chloride. Each Doxazosin Tablet, USP, for oral
administration, contains 1 mg, 2 mg, 4 mg and
8 mg of doxazosin as the free base.
In addition, each Doxazosin Tablet, USP contains the following
inactive ingredients: croscarmellose
sodium, lactose monohydrate, magnesium stearate and microcrystalline
cellulose.
CLINICAL PHARMACOLOGY
PHARMACODYNAMICS
A. _BENIGN PROSTATIC HYPERPLASIA (BPH)_
Benign prostatic hyperplasia (BPH) is a common cause of urinary
outflow obstruction in aging males.
Severe BPH may lead to urinary retention and renal damage. A static
and a dynamic component
contribute to the symptoms and reduced urinary flow rate associated
with BPH. The static component is
related to an increase in prostate size caused, in part, by a
proliferation of smooth muscle cells in the
prostatic stroma. However, the severity of BPH symptoms and the degree
of urethral obstruction do not
correlate well with the size of the prostate. The dynamic component of
BPH is associated with an
increase in smooth muscle tone in the prostate and bladder neck. The
degree of tone in this area is
mediated by the alpha adrenoceptor, which is present in high density
in the prostatic stroma, prostatic
capsule and bladder neck. Blockade of the alpha
receptor decreases urethral resistance and may relieve