CHOLESTYRAMINE powder for suspension

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

CHOLESTYRAMINE (UNII: 4B33BGI082) (CHOLESTYRAMINE - UNII:4B33BGI082)

Mevcut itibaren:

Golden State Medical Supply, Inc.

INN (International Adı):

CHOLESTYRAMINE

Kompozisyon:

CHOLESTYRAMINE 4 g in 9 g

Reçete türü:

PRESCRIPTION DRUG

Yetkilendirme durumu:

Abbreviated New Drug Application

Ürün özellikleri

CHOLESTYRAMINE- CHOLESTYRAMINE POWDER, FOR SUSPENSION
CHOLESTYRAMINE LIGHT- CHOLESTYRAMINE LIGHT POWDER, FOR SUSPENSION
GOLDEN STATE MEDICAL SUPPLY, INC.
----------
CHOLESTYRAMINE FOR ORAL SUSPENSION USP AND CHOLESTYRAMINE FOR ORAL
SUSPENSION USP, LIGHT
DESCRIPTION
Cholestyramine for Oral Suspension USP, the chloride salt of a basic
anion exchange resin, a
cholesterol lowering agent, is intended for oral administration.
Cholestyramine resin is quite
hydrophilic, but insoluble in water. The cholestyramine resin in
Cholestyramine is not absorbed from
the digestive tract. Four grams of anhydrous cholestyramine resin is
contained in 9 grams of
Cholestyramine for Oral Suspension USP. Four grams of anhydrous
cholestyramine resin is contained
in 5 grams of Cholestyramine for Oral Suspension USP, Light. It is
represented by the following
structural formula:
Cholestyramine for Oral Suspension USP contains the following inactive
ingredients: acacia, citric
acid, D&C Yellow No. 10, FD&C Yellow No. 6, flavor (natural and
artificial Orange), polysorbate 80,
propylene glycol alginate and sucrose. Cholestyramine for Oral
Suspension USP, Light contains the
following inactive ingredients: aspartame, citric acid, colloidal
silicon dioxide, D&C Yellow No. 10,
FD&C Red No. 40, flavor (natural and artificial Orange), maltodextrin,
propylene glycol alginate and
xanthan gum.
CLINICAL PHARMACOLOGY
Cholesterol is probably the sole precursor of bile acids. During
normal digestion, bile acids are
secreted into the intestines. A major portion of the bile acids is
absorbed from the intestinal tract and
returned to the liver via the enterohepatic circulation. Only very
small amounts of bile acids are found in
normal serum.
Cholestyramine resin adsorbs and combines with the bile acids in the
intestine to form an insoluble
complex which is excreted in the feces. This results in a partial
removal of bile acids from the
enterohepatic circulation by preventing their absorption.
The increased fecal loss of bile acids due to Cholestyramine
administr