Ülke: Avustralya
Dil: İngilizce
Kaynak: Department of Health (Therapeutic Goods Administration)
amitriptyline hydrochloride
Apotex Pty Ltd
amitriptyline hydrochloride
Registered
CHEMMART AMITRIPTYLINE _Contains the active ingredient amitriptyline (as hydrochloride)_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about amitriptyline. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Chemmart Amitriptyline Tablets. It contains the active ingredient amitriptyline hydrochloride. It is used to treat: • major depression - the 10 mg and 25 mg tablets can be used at any stage in treatment, however, the 50 mg tablets are approved only for maintenance treatment (i.e. after symptoms have improved). • Bed wetting, provided there is no physical cause (e.g. problems with the bladder). Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS_ Amitriptyline belongs to a group of medicines called tricyclic antidepressants (TCAs). TCAs work by correcting the imbalance of certain chemicals in the brain. These chemicals, called ami Belgenin tamamını okuyun
Product Information – Australia Chemmart Amitriptyline Tablets Page 1 CHEMMART AMITRIPTYLINE TABLETS NAME OF THE MEDICINE Amitriptyline hydrochloride ACTIVE INGREDIENT Chemical Name: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N- dimethylpropylamine hydrochloride Structural Formula: Molecular Formula: C 20 H 23 N.HCl Molecular Weight: 313.9 CAS Registry Number: 549-18-8 DESCRIPTION Amitriptyline hydrochloride occurs as colourless crystals or a white or almost white powder; odourless or almost odourless; taste, bitter and burning, followed by a sensation of numbness. It is soluble in 1 part of water, in 1.5 parts of ethanol (96%), in 1.2 parts of chloroform and in 1 part of methanol. It is practically insoluble in ether. pKa of amitriptyline hydrochloride is 9.4. Each tablet contains amitriptyline hydrochloride as the active ingredient. In addition, each tablet contains the following inactive ingredients: lactose, microcrystalline cellulose, crospovidone, maize starch, colloidalanhydrous silica, purified talc, magnesium stearate, hypromellose, titanium dioxide, macrogol 6000, brilliant blue FCF aluminium lake (10mg only), quinoline yellow aluminium lake (25mg only), sunset yellow FCF aluminium lake and indigo carmine aluminium lake (50mg only). PHARMACOLOGY Amitriptyline is a tricyclic antidepressant with sedative properties. MECHANISM OF ACTION The mechanism of action of amitriptyline in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system. In broad clinical use, amitriptyline has been found to be well tolerated. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of noradrenaline and serotonin in adrenergic and serotonergic neurons. Pharmacologically, this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating its transmitting activity. This interference with the uptake of noradrenaline and/or serotonin is believed by Belgenin tamamını okuyun