Ülke: Kanada
Dil: İngilizce
Kaynak: Health Canada
CEFTAZIDIME (CEFTAZIDIME PENTAHYDRATE)
STERIMAX INC
J01DD02
CEFTAZIDIME
3G
POWDER FOR SOLUTION
CEFTAZIDIME (CEFTAZIDIME PENTAHYDRATE) 3G
INTRAVENOUS
10X3G
Prescription
THIRD GENERATION CEPHALOSPORINS
Active ingredient group (AIG) number: 0116900010; AHFS:
APPROVED
2015-04-02
PRODUCT MONOGRAPH PR CEFTAZIDIME FOR INJECTION BP (as ceftazidime pentahydrate) 1 G/VIAL, 2 G/VIAL, 3 G/VIAL, 6 G/VIAL Sterile Powder for Solution ANTIBIOTIC SteriMax Inc. Date of Revision: February 9, 2018 2770 Portland Drive Oakville, ON L6H 6R4 Control No.: 212129 _Ceftazidime for Injection BP _ _ _ _Page 2 of 51 _ _ _ PRODUCT MONOGRAPH PR CEFTAZIDIME FOR INJECTION BP (as ceftazidime pentahydrate) 1 G/VIAL, 2 G/VIAL, 3 G/VIAL, 6 G/VIAL Sterile Powder for Solution ANTIBIOTIC CLINICAL PHARMACOLOGY _In vitro _ studies indicate that the bactericidal action of ceftazidime, a semisynthetic cephalosporin antibiotic, results from inhibition of bacterial cell wall synthesis. Ceftazidime has a high affinity for the Penicillin-Binding Protein-3 (PBP-3) and moderate affinity for the PBP-1a of certain Gram negative organisms such as _Escherichia _coli and _Pseudomonas aeruginosa_. The affinity for PBP-1b is much less than that for either PBP-3 or PBP-1a. PBP-3 is involved in the process of cross-wall formation (septation). Binding to this protein results in formation of filaments and eventual death of the bacterium. PBP-1a and PBP-1b are involved in longitudinal wall synthesis (elongation) prior to septation. Binding to these proteins results in spheroplast formation followed by rapid lysis. Ceftazidime has high affinity for PBP-1 and PBP-2 of _ Staphylococcus aureus_. However, the drug's affinity for PBP-3 is very much less in this organism. INDICATIONS AND CLINICAL USE Ceftazidime for Injection BP may be indicated for the treatment of patients with infections caused by susceptible strains of the designated organisms in the following diseases: LOWER RESPIRATORY TRACT INFECTIONS Pneumonia caused by _ Pseudomonas aeruginosa_; _ Haemophilus influenzae _including ampicillin-resistant strains; _ Klebsiella _ species; _ Enterobacter _ species; _ Proteus mirabilis;_ _ Escherichia coli, Serratia _ species, _Streptococcus pneumoniae_, and _Staphylococcus_ _aureus_ (methicillin susceptible) strains. _Ceftazidime for Injection BP _ Belgenin tamamını okuyun