Ülke: ABD
Dil: İngilizce
Kaynak: NLM (National Library of Medicine)
CEFOXITIN SODIUM (UNII: Q68050H03T) (CEFOXITIN - UNII:6OEV9DX57Y)
Apotex Corporation
CEFOXITIN SODIUM
CEFOXITIN 1 g
PRESCRIPTION DRUG
Abbreviated New Drug Application
CEFOXITIN- CEFOXITIN INJECTION, POWDER, FOR SOLUTION APOTEX CORPORATION ---------- CEFOXITIN FOR INJECTION, USP ONLY To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefoxitin for injection and other antibacterial drugs, cefoxitin for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION Cefoxitin for injection is a semi-synthetic, broad-spectrum cepha antibiotic sealed under nitrogen for intravenous administration. It is derived from cephamycin C, which is produced by _Streptomyces_ _lactamdurans._ Its chemical name is sodium (6R,7_S_)-3-(hydroxymethyl)-7-methoxy-8-oxo-7-[2-(2- thienyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate carbamate (ester). The molecular formula is C H N NaO S , and the structural formula is: Cefoxitin for injection contains approximately 53.8 mg (2.3 milliequivalents) of sodium per gram of cefoxitin activity. Solutions of cefoxitin for injection range from colorless to light amber in color. The pH of freshly constituted solutions usually ranges from 4.2 to 7. Each conventional vial contains sterile cefoxitin sodium, USP equivalent to 1 or 2 g cefoxitin. CLINICAL PHARMACOLOGY _CLINICAL PHARMACOLOGY_ Following an intravenous dose of 1 gram, serum concentrations were 110 mcg/mL at 5 minutes, declining to less than 1 mcg/mL at 4 hours. The half-life after an intravenous dose is 41 to 59 minutes. Approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6 hour period, resulting in high urinary concentrations. Probenecid slows tubular excretion and produces higher serum levels and increases the duration of measurable serum concentrations. Cefoxitin passes into pleural and joint fluids and is detectable in antibacterial concentrations in bile. In a published study of geriatric patients ranging in age from 64 to 88 years with normal renal function for their age (creatinine clearance ranging from 31.5 to 174.0 mL/min), the half-life for Belgenin tamamını okuyun