Ülke: Avustralya
Dil: İngilizce
Kaynak: Department of Health (Therapeutic Goods Administration)
caspofungin
Mayne Pharma International Pty Ltd
Caspofungin
Registered
CASPOFUNGIN MYX™ _FOR INTRAVENOUS INFUSION _ _Caspofungin acetate _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Caspofungin MYX. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using Caspofungin MYX against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET. You may need to read it again. WHAT CASPOFUNGIN MYX IS USED FOR Caspofungin MYX is used to treat the following fungal infections: • Invasive candidiasis, including candidaemia • Oesophageal candidiasis • Invasive aspergillosis, when other antifungal treatments have not worked or when other antifungal treatments have not been tolerated. Also, your doctor may suspect that you have a fungal infection in the following situation, and prescribe Caspofungin MYX to treat it. • Chemotherapy or other medical treatments or conditions can lower the body's resistance to disease by lowering counts of certain white blood cells. If you have persistent fever following chemotherapy or under other conditions as noted above, and your fever is not reduced by treatment with an antibiotic, you may have a fungal infection. Candidiasis is an infection caused by a fungus (yeast) called candida. Invasive candidiasis is a serious type of candidiasis which occurs in your bloodstream (referred to as candidaemia), or in tissues or organs such as the lining of the abdomen (peritonitis), the heart, kidneys, liver, bones, muscles, joints, spleen, or eyes. Candidiasis can also occur in your food pipe, also known as the oesophagus (oesophageal candidiasis). It may cause difficulty or pain when swallowing. Invasive aspergillosis is an infection caused by a fungus, called aspergillus (as-pur-jilus). Most of these infections begin in the respiratory tract (in the nose, sinuses, or Belgenin tamamını okuyun
Product Information CASPOFUNGIN MYX™ POWDER FOR INJECTION NAME OF THE MEDICINE Caspofungin acetate Caspofungin acetate is 1-[(4 _R_ ,5 _S_ )-5-[(2-aminoethyl)amino]- _N_ 2 -(10,12- dimethyl-1- oxotetradecyl)-4-hydroxy- _L-_ ornithine]-5-[(3 _R_ )-3-hydroxy- _L_ - ornithine]pneumocandin B 0 diacetate (salt). The empirical formula is C 52 H 88 N 10 O 15 •2C 2 H 4 O 2 and the formula weight is 1213.42. The CAS No is 179463-17-3. The structural formula is: DESCRIPTION Caspofungin MYX is a sterile, lyophilised product for intravenous infusion that contains a semisynthetic lipopeptide (echinocandin) compound synthesised from a fermentation product of Pneumocandin B 0 _. _ Caspofungin acetate belongs to a class of antifungal drugs (echinocandins) that inhibit the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. Caspofungin acetate is a hygroscopic, white to off-white powder. It is freely soluble in water and methanol, and slightly soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. In addition to the active ingredient caspofungin acetate, Caspofungin MYX contains the following inactive ingredients: sucrose, mannitol, glacial acetic acid, and sodium hydroxide. v 1.0 1 Product Information PHARMACOLOGY MECHANISM OF ACTION Caspofungin acetate, the active ingredient of Caspofungin MYX, inhibits the synthesis of β (1,3)-D-glucan, an essential component of the cell wall of many filamentous fungi and yeast. β (1,3)-D-glucan is not present in mammalian cells. MICROBIOLOGY ACTIVITY _IN VITRO_ Caspofungin has _in vitro _ activity against: _Aspergillus _ species (including _Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, _ _Aspergillus nidulans, Aspergillus terreus and Aspergillus candidus_ ) _Candida _ species (including _Candida albicans, Candida dublinensis_ , _Candida glabrata, _ _Candida guilliermondii, Candida kefyr, Candida krusei, Candida lipolytica, Candida _ _lusitaniae, Candida parapsilosis_ , _Candida rugosa, _ and _Can Belgenin tamamını okuyun