Benpen

Ülke: Yeni Zelanda

Dil: İngilizce

Kaynak: Medsafe (Medicines Safety Authority)

Aktif bileşen:

Benzylpenicillin sodium 3 g

Mevcut itibaren:

Seqirus (NZ) Ltd

INN (International Adı):

Benzylpenicillin sodium 3 g

Doz:

3 g

Farmasötik formu:

Powder for injection

Kompozisyon:

Active: Benzylpenicillin sodium 3 g

Paketteki üniteler:

Vial, glass, Type III, 3 g

Sınıf:

Prescription

Reçete türü:

Prescription

Tarafından üretildi:

Sandoz GmbH

Ürün özeti:

Package - Contents - Shelf Life: Vial, glass, Type III - 3 g - 60 months from date of manufacture stored at or below 25°C

Yetkilendirme tarihi:

1994-02-07

Bilgilendirme broşürü

1 

BENPEN
TM

_Benzylpenicillin (as benzylpenicillin sodium)
Powder for Injection_ 

CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET

This leaflet answers some common questions about BENPEN
TM
.   
It does not contain all the available information. 
It does not take the place of talking to your doctor
and pharmacist. 

All medicines have risks and benefits. Your doctor has
weighed the risks of you taking BENPEN
TM
 against the 
benefits this medicine is expected to have for you. 

IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST. 

Keep this leaflet.  You may need to read it again. 

WHAT BENPEN
TM
 IS USED FOR 

BENPEN
TM
 is an antibiotic used to treat some infections in different
parts of the body caused by bacteria. 

BENPEN
TM
 may also be used to prevent
infections before, during and after surgery. 

BENPEN
TM
 will not work against infections caused by viruses, such as
colds or the flu. 

BENPEN
TM
 is an antibiotic that belongs to a group of
medicines called penicillins. 
These antibiotics work by killing 
the bacteria that are causing your infection. 

Your doctor may have prescribed BENPEN
TM
 for another reason.  Ask your doctor why BENPEN
TM
 has been 
prescribed for you. 

This medicine is available only with a doctors prescription. 

There is no evidence that BENPEN
TM
 is addictive. 

BEFORE YOU ARE GIVEN BENPEN
TM

_WHEN YOU MUST NOT BE GIVEN IT_ 

DO NOT USE BENPEN
TM
 IF: 

∃  YOU HAVE AN ALLERGY TO BENPEN
TM
 OR OTHER PENICILLINS. 
Some of the symptoms of
an allergic reaction may include skin rash, itching and difficult
breathing. 

∃  YOU HAVE HAD AN ALLERGIC REACTION TO CEPHALOSPORINS. 
You may have an increased chance of being allergic to BENPEN
TM
 if you

Ürün özellikleri

Page 1 of 3 
NAME OF MEDICINE 
BENPEN INJECTION 
Benzylpenicillin Sodium 600mg, 1.2g and 3g/vial 

PRESENTATION 

White powder in vial nominally containing 600mg, 1.2g or 3g of
Benzylpenicillin Sodium.  These 
presentations contain no other excipients. 

USES 

ACTIONS  
Benzylpenicillin is bactericidal and is active against most
Gram-positive organisms e.g. 
pneumococci, streptococci, non-beta-lactamase-
producing staphylococci, clostridia and some 
Gram-negative organisms, eg. gonococci and meningococci.  It is also
active against spirochetes 
such as _Treponema pallidum_ 

PHARMACOKINETICS 
Benzylpenicillin appears rapidly in the blood after intramuscular
injection, maximum concentrations 
being reached in 20 to 30 minutes.  The concentration with
a particular dose varies in different 
patients and in the same patient on different occasions.  Serum
concentrations of penicillin have 
been reported to range from 1.2 to 12 µg per mL, 3 to 6 hours after
the intramuscular injection of 
60 to 600 mg.  The minimum effective serum-penicillin concentration
is about 0.02 µg per mL for 
sensitive organisms, but higher levels (0.03 to 0.06 µg per mL) are
required in the treatment of 
sub-acute bacterial endocarditis or infections due to relatively less
sensitive organisms.  The half-
life of benzylpenicillin when given intramuscularly is 30 minutes. 

Benzylpenicillin diffuses across the placenta into the foetal
circulation and small amounts may 
appear in the milk of nursing mothers.  However, very little passes
into the cerebrospinal fluids 
except when the meninges are inflamed.  Small amounts are excreted
in the bile.  It is rapidly 
excreted by the renal tubules, causing a steep decline
in serum-penicillin concentrations; up to 
60% of a single intramuscular dose may appear in the urine within 1
hour of administration and 
95% within 4 hours.  The renal tubular excretion of penicillin can
be partly blocked by probenecid, 
but t