Ülke: Avustralya
Dil: İngilizce
Kaynak: Department of Health (Therapeutic Goods Administration)
metformin hydrochloride, Quantity: 850 mg
Arrotex Pharmaceuticals Pty Ltd
Metformin hydrochloride
Tablet, film coated
Excipient Ingredients: magnesium stearate; povidone; hypromellose; macrogol 6000; macrogol 400
Oral
100, 60
(S4) Prescription Only Medicine
Metformin is indicated in the treatment of type 2 diabetes mellitus in adults, children from 10 years of age and adolescents, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycaemic control.,For adult patients, metformin may be used as initial treatment or in sulfonylurea failures either alone or in combination with a sulfonylurea and other oral agents or as adjuvant therapy in insulin requiring type 2 diabetes.
Visual Identification: White, biconvex, circular shaped, film coated tablets with 'A' debossed on one side and '61' debossed on the other side; Container Type: Bottle; Container Material: HDPE; Container Life Time: 4 Years; Container Temperature: Store below 25 degrees Celsius; Container Closure: Child resistant closure
Registered
2011-11-24
AURO-METFORMIN CONSUMER MEDICINE INFORMATION Version 1.2 Page 1 of 6 AURO-METFORMIN 500, 850 & 1000 Metformin hydrochloride CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about AURO- METFORMIN. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist or diabetes educator. All medicines have risks and benefits. Your doctor has weighed the risks of you taking AURO- METFORMIN against the benefits it is expected for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST OR DIABETES EDUCATOR . KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT AURO-METFORMIN IS USED FOR AURO-METFORMIN is used to control blood glucose (the amount of sugar in the blood) in people with diabetes mellitus. AURO-METFORMIN can be used in type 2 diabetes in adults and children over 10 years of age. It is especially useful in those who are overweight, when diet and exercise are not enough to lower high blood glucose levels (hyperglycaemia). For adult patients, AURO-METFORMIN can be used alone, or in combination with other oral diabetic medicines or in combination with insulin in insulin requiring type 2 diabetes. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY AURO- METFORMIN HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed AURO-METFORMIN for another reason. AURO-METFORMIN is available only with a doctor’s prescription. There is no evidence that AURO- METFORMIN is addictive. _HOW AURO-METFORMIN WORKS _ AURO-METFORMIN belongs to a group of medicines called biguanides. AURO-METFORMIN lowers high blood glucose (hyperglycaemia) by helping your body make better use of the insulin produced by your pancreas. People with type 2 diabetes are unable to make enough insulin or their body does not respond properly to the insulin it does make. This causes a build up of glucose in the blood, which can lead to serious medical problems. Long-term hyperglycaemia can lead to heart Belgenin tamamını okuyun
Product Information: AURO-METFORMIN 500, 850 & 1000 (Metformin Tablets 500mg, 850mg & 1000mg) Ver 1.3 Page 1 of 11 PRODUCT INFORMATION AURO-METFORMIN 500 (500MG METFORMIN HYDROCHLORIDE) AURO-METFORMIN 850 (850MG METFORMIN HYDROCHLORIDE) AURO-METFORMIN 1000 (1000MG METFORMIN HYDROCHLORIDE) LIFE THREATENING LACTIC ACIDOSIS CAN OCCUR DUE TO ACCUMULATION OF METFORMIN. THE MAIN RISK FACTOR IS RENAL IMPAIRMENT, OTHER RISK FACTORS INCLUDE OLD AGE ASSOCIATED WITH REDUCED RENAL FUNCTION AND HIGH DOSES OF METFORMIN ABOVE 2 G PER DAY. NAME OF MEDICINE The name of the medicine is metformin hydrochloride CHEMICAL NAME: _1,1-dimethyldiguanide hydrochloride._ MOLECULAR FORMULA: C 4 H 11 N 5 • HCl MOLECULAR WEIGHT: 165.6 CAS REGISTRY NUMBER: [1115–70–4] DESCRIPTION Metformin hydrochloride is a white, crystalline powder. It is freely soluble in water, slightly soluble in ethanol and practically insoluble in acetone and in methylene chloride. INACTIVE: Povidone, magnesium stearate and Opadry complete film coating system YS-1R-7006 Clear (PI-ARTG No. 13068). PHARMACOLOGY Metformin is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycaemia. Metformin may act via 3 mechanisms: 1) Reduction of hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis 2) In muscle, by increasing insulin sensitivity, improving peripheral glucose uptake and utilisation 3) Delay of intestinal glucose absorption. Metformin stimulates intracellular glycogen synthesis by acting on glycogen synthase. H 2 N N N CH 3 NH NH CH 3 H , HCl Product Information: AURO-METFORMIN 500, 850 & 1000 (Metformin Tablets 500mg, 850mg & 1000mg) Ver 1.3 Page 2 of 11 Metformin increases the transport capacity of all types of membrane glucose transporters (GLUT). In humans, independently of its action on glycaemia, metformin has favourable effects on lipid metabolism. This has been shown at therapeutic doses in controlled, medium-te Belgenin tamamını okuyun