ALPHAQUIN HP hydroquinone octinoxate and oxybenzone cream

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

Hydroquinone (UNII: XV74C1N1AE) (Hydroquinone - UNII:XV74C1N1AE)

Mevcut itibaren:

Stratus Pharamceuticals

INN (International Adı):

Hydroquinone

Kompozisyon:

Hydroquinone 40 mg in 1 g

Reçete türü:

PRESCRIPTION DRUG

Yetkilendirme durumu:

unapproved drug other

Ürün özellikleri

ALPHAQUIN HP- HYDROQUINONE, OCTINOXATE, AND OXYBENZONE CREAM
STRATUS PHARAMCEUTICALS
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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ALPHAQUIN HP
4% CREAM RX
(HYDROQUINONE 4% USP
SKIN BLEACHING MOISTURIZING
TOPICAL CREAM WITH SUNSCREENS)
Rx only
FOR EXTERNAL USE ONLY: NOT FOR OPHTHALMIC, NASAL OR OTIC USE.
DESCRIPTION
Each gram of ALPHAQUIN HP 4% CREAM Contains: ACTIVE: 40 mg of
Hydroquinone USP,
7.5% Octyl Methoxycinnamate,5.0% Benzophenone-3 in a cream base of:
INACTIVES: Purified Water,
Propylene Glycol, Glycerine, Cetyl Alcohol, Cetostearyl Alcohol,
Glycolic Acid, Isopropyl Palmitate,
Stearyl Alcohol, Sodium Lauryl Sulfate, Sodium Metabisulfite, Citric
Acid, Sorbic Acid and Sodium
Hydroxide.
Hydroquinone is 1, 4-Benzenediol, with a chemical formula of C6H6O2
and a molecular weight of
110.11.
The structural formula is:
CLINICAL PHARMACOLOGY
Topical application of hydroquinone produces a reversible
depigmentation of the skin by the inhibition
of the enzymatic oxidation of tyrosine to 3, 4-dihydroxyphenylalanine
(DOPA) [Denton, C., et al., 1952
(1)] and suppression of other melanocyte metabolic processes [Jimbow,
K., et al., 1974 (2)]. Exposure
to sunlight or ultraviolet light will cause repigmentation of the
bleached areas [Parrish, J.A. et al., 1978
(3)].
INDICATIONS AND USAGE
®
®
®
ALPHAQUIN HP 4% CREAM is indicated for the gradual bleaching of
hyperpigmented skin
conditions such as chloasma, melasma, freckles, senile lentigines and
other undesired areas of melanin
hyperpigmentation.
CONTRAINDICATIONS
ALPHAQUIN HP 4% CREAM is contraindicated in persons who have shown
hypersensitivity to
hydroquinone or any of the other ingredients. The safety of topical
treatment of hydroquinone during
pregnancy or in children (12 years and under) has not been
established. (See PRECAUTIONS).
WARNINGS
1. Hydroquinone is a skin bleaching agent which may produce undesired
effects