ACYCLOVIR suspension

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

ACYCLOVIR (UNII: X4HES1O11F) (ACYCLOVIR - UNII:X4HES1O11F)

Mevcut itibaren:

Akorn

INN (International Adı):

ACYCLOVIR

Kompozisyon:

ACYCLOVIR 200 mg in 5 mL

Uygulama yolu:

ORAL

Reçete türü:

PRESCRIPTION DRUG

Terapötik endikasyonlar:

Acyclovir oral suspension, USP is indicated for the acute treatment of herpes zoster (shingles). Acyclovir oral suspension, USP is indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes. Acyclovir oral suspension, USP is indicated for the treatment of chickenpox (varicella). Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

Ürün özeti:

Acyclovir oral suspension, USP (off-white, artificial banana-flavored) containing 200 mg acyclovir in each teaspoonful (5 mL) – Bottle of 1 pint (473 mL). Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light. Distributed by: Akorn Operating Company LLC Gurnee, IL 60031 Rev.810:03 08/22

Yetkilendirme durumu:

Abbreviated New Drug Application

Ürün özellikleri

ACYCLOVIR- ACYCLOVIR SUSPENSION
AKORN
----------
ACYCLOVIR ORAL SUSPENSION, USP 200 MG/5 ML
DESCRIPTION
Acyclovir is a synthetic nucleoside analogue active against
herpesviruses.
Each teaspoonful (5 mL) of acyclovir oral suspension, USP, for oral
administration,
contains 200 mg of acyclovir and the inactive ingredients artificial
banana flavor,
carboxymethylcellulose sodium, glycerin, methylparaben 0.1% (added as
a
preservative), microcrystalline cellulose, propylparaben 0.02% (added
as a preservative),
purified water, and sorbitol.
Acyclovir is a white, crystalline powder with the molecular formula C
H
N O and a
molecular weight of 225. The maximum solubility in water at 37°C is
2.5 mg/mL. The
pka’s of acyclovir are 2.27 and 9.25.
The chemical name of acyclovir is
2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-
6H-purin-6-one; it has the following structural formula:
VIROLOGY:
MECHANISM OF ANTIVIRAL ACTION:
Acyclovir is a synthetic purine nucleoside analogue with _in vitro_
and _in vivo_ inhibitory
activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and
varicella-zoster
virus (VZV).
The inhibitory activity of acyclovir is highly selective due to its
affinity for the enzyme
thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme
converts acyclovir
into acyclovir monophosphate, a nucleotide analogue. The monophosphate
is further
converted into diphosphate by cellular guanylate kinase and into
triphosphate by a
number of cellular enzymes. _In vitro_, acyclovir triphosphate stops
replication of herpes
viral DNA. This is accomplished in 3 ways: 1) competitive inhibition
of viral DNA
polymerase, 2) incorporation into and termination of the growing viral
DNA chain, and 3)
inactivation of the viral DNA polymerase. The greater antiviral
activity of acyclovir against
HSV compared with VZV is due to its more efficient phosphorylation by
the viral TK.
ANTIVIRAL ACTIVITIES:
8
11
5
3
The quantitative relationship between the _in vitro_ susceptibility of
herpes viruses to
antivirals and the clinical r