ZOVIRAX 800mg dispersible tablet

Nchi: Australia

Lugha: Kiingereza

Chanzo: Department of Health (Therapeutic Goods Administration)

Viambatanisho vya kazi:

aciclovir

Inapatikana kutoka:

GlaxoSmithKline Australia Pty Ltd

Idhini hali ya:

Registered

Taarifa za kipeperushi

ZOVIRAX
®
_800 MG TABLETS (120 TABLET PACK)_
_aciclovir_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
The information provided in this
leaflet applies to usage of the 120
tablet packs.
This leaflet answers some common
questions about Zovirax. It does not
contain all of the available
information.
Reading this leaflet does not take the
place of talking to your doctor or
pharmacist.
Taking any medicine involves some
risk. It is possible that all risks
associated with this medicine might
not have been detected, despite
proper testing. Only your doctor or
pharmacist is able to weigh up all of
the relevant facts, and you should
consult them if you have any queries.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING ZOVIRAX ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS INFORMATION.
You may want to read it again.
This leaflet provides information
about Zovirax.
The statements that are made in this
leaflet cannot be applied to any other
medicine, even those that are similar
or appear to contain the same
ingredients.
WHAT ZOVIRAX IS USED
FOR
Zovirax is used as part of the
management program for certain
infections in people who also have
the human immunodeficiency virus
(HIV). HIV is the virus that causes
acquired immune deficiency
syndrome (AIDS).
Zovirax does not cure AIDS or get
rid of the HIV virus from your body,
but it may prevent further damage to
the immune system by stopping
production of herpes viruses.
_HOW DOES ZOVIRAX WORK?_
Aciclovir (the active ingredient in
Zovirax) belongs to a group of
medicines called "antivirals".
Zovirax works by stopping the
production of the viruses that cause
herpes and shingles.
Your doctor may, however, have
prescribed Zovirax for a different use
to that described above.
IF YOU HAVE ANY QUESTIONS ABOUT
WHY YOU ARE TAKING ZOVIRAX ASK
YOUR DOCTOR OR PHARMACIST.
Your doctor or pharmacist will be
able to provide you with more
information.
BEFORE YOU TAKE
ZOVIRAX
ZOVIRAX IS NOT SUITABLE FOR
EVERYONE.
BE SURE THAT YOUR DOCTOR KNOWS
ABOUT THE FOLLOWING BEFORE YOU TAKE
ZOVIRAX:
1.
IF YOU ARE ALLER

Tabia za bidhaa

1
ZOVIRAX
®
TABLETS AND ZOVIRAX
®
DISPERSIBLE TABLETS
NAME OF THE DRUG:
Aciclovir
_Chemical name:_ 9-((2-hydroxyethoxy)methyl)guanine
_Chemical Structure _
N
HN
N
N
O
H
2
N
O
HO
_ _
_CAS Number_: 59277-89-3
DESCRIPTION:
Aciclovir is a synthetic acyclic purine nucleoside analogue. It is a
white crystalline powder slightly
soluble in water and practically insoluble in most organic solvents.
The chemical structure of
aciclovir is:
Each Zovirax tablet contains 200 mg, 400 mg or 800 mg of aciclovir.
Zovirax Dispersible Tablets (200 mg, 400 mg and 800 mg) contain the
excipients cellulose-
microcrystalline, aluminium magnesium silicate, sodium starch
glycollate, povidone, magnesium
stearate, Opadry Complete film coating system White Y-1-7000 and
macrogol 8000.
Zovirax 200 mg Tablets contain the excipients
cellulose-microcrystalline, lactose monohydrate,
magnesium stearate, povidone and sodium starch glycollate.
Zovirax 400 mg and 800 mg Tablets contain the excipients
cellulose-microcrystalline, magnesium
stearate, povidone and sodium starch glycollate.
PHARMACOLOGY:
MICROBIOLOGY:
Aciclovir is an antiviral agent which is active _in vitro_ against
_Herpes simplex_ virus (HSV) types I
and II
and
_Varicella _
_zoster_
virus (VZV),
the
latter
being
considerably
less sensitive.
The
relationship between the level of _ in vitro_ sensitivity of herpes
viruses to aciclovir and clinical
response to therapy has not been adequately established. Development
of resistance by HSV to
aciclovir has been documented. Aciclovir needs to be phosphorylated to
the active compound,
aciclovir triphosphate, in order to become active against the virus.
Such conversion is very limited
in normal cells and in addition cellular DNA polymerase is not very
sensitive to the active
compound. However,
in infected cells HSV or VZV-coded thymidine kinase facilitates the
conversion
of
aciclovir
to
aciclovir
monophosphate
which
is
then
converted
to
aciclovir
2
triphosphate by cellular enzymes. Aciclovir triphosphate acts as an
inhibitor of, and substrate for