TRIAMTERENE AND HYDROCHLOROTHIAZIDE capsule

Nchi: Marekani

Lugha: Kiingereza

Chanzo: NLM (National Library of Medicine)

Viambatanisho vya kazi:

HYDROCHLOROTHIAZIDE (UNII: 0J48LPH2TH) (HYDROCHLOROTHIAZIDE - UNII:0J48LPH2TH)

Inapatikana kutoka:

Avera McKennan Hospital

INN (Jina la Kimataifa):

HYDROCHLOROTHIAZIDE

Tungo:

HYDROCHLOROTHIAZIDE 25 mg

Dawa ya aina:

PRESCRIPTION DRUG

Idhini hali ya:

Abbreviated New Drug Application

Tabia za bidhaa

TRIAMTERENE AND HYDROCHLOROTHIAZIDE- TRIAMTERENE AND
HYDROCHLOROTHIAZIDE CAPSULE
AVERA MCKENNAN HOSPITAL
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DESCRIPTION
Each triamterene and hydrochlorothiazide capsule for oral
administration contains hydrochlorothiazide
25 mg and triamterene 37.5 mg. Hydrochlorothiazide is a
diuretic/antihypertensive agent and triamterene
is an antikaliuretic agent.
Hydrochlorothiazide is slightly soluble in water. It is soluble in
dilute ammonia, dilute aqueous sodium
hydroxide and dimethylformamide. It is sparingly soluble in methanol.
Hydrochlorothiazide is 6-Chloro-3,4-dihydro-2_H_
-1,2,4-benzothiadiazine-7- sulfonamide 1,1-dioxide,
and its structural formula is:
At 50°C, triamterene is practically insoluble in water (less than
0.1%). It is soluble in formic acid,
sparingly soluble in methoxyethanol, and very slightly soluble in
alcohol.
Triamterene is 2,4,7-Triamino-6-phenylpteridine and its structural
formula is:
Inactive ingredients consist of black iron oxide, colloidal silicon
dioxide, croscarmellose sodium,
FD&C Blue No. 1, gelatin, magnesium stearate, microcrystalline
cellulose, polyethylene glycol,
polysorbate 80, silicon dioxide, sodium bicarbonate, sodium lauryl
sulfate, titanium dioxide and yellow
iron oxide.
The black imprinting ink also contains the following inactive
ingredients: D&C Yellow No. 10
Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, FD&C Blue No. 2 Aluminum
Lake, FD&C Red No.
40 Aluminum Lake, pharmaceutical glaze, propylene glycol and synthetic
black iron oxide.
Triamterene and Hydrochlorothiazide Capsules, USP 37.5 mg/25 mg meet_
USP Dissolution Test 3._
CLINICAL PHARMACOLOGY
The triamterene and hydrochlorothiazide capsule is a
diuretic/antihypertensive drug product that
combines natriuretic and antikaliuretic effects. Each component
complements the action of the other.
The hydrochlorothiazide component blocks the reabsorption of sodium
and chloride ions, and thereby
increases the quantity of sodium traversing the distal tubule and the
volume of water excreted. A portion
of the additional