Terry White Chemists Escitalopram

Nchi: Australia

Lugha: Kiingereza

Chanzo: Department of Health (Therapeutic Goods Administration)

Viambatanisho vya kazi:

Escitalopram oxalate

Inapatikana kutoka:

Apotex Pty Ltd

Darasa:

Medicine Registered

Taarifa za kipeperushi

TERRY WHITE CHEMISTS
ESCITALOPRAM

_Contains the active ingredient, escitalopram (as escitalopram
oxalate)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about escitalopram.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is Terry
White Chemists Escitalopram. It
contains the active ingredient,
escitalopram (as escitalopram
oxalate).
It is used to treat depression.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Escitalopram belongs to a group of
medicines called Selective Serotonin
Reuptake Inhibitors (SSRIs).
Escitalopram and other SSRIs are
thought to help by increasing the
amount of serotonin in your brain.
Depression is longer lasting or more
severe than the "low moods"
everyone has from time to time due
to the stress of everyday life. It is
thought to be caused by a chemical
imbalance in parts of the brain. This
imbalance affects your whole body
and can cause emotional and physical
symptoms such as feeling low in
spirit, loss of interest i

Tabia za bidhaa

Product Information – Australia 
Terry White Chemists Escitalopram Tablets_m 
Page 1 
TERRY WHITE CHEMISTS ESCITALOPRAM TABLETS 

NAME OF THE MEDICINE 
Escitalopram oxalate. 

Chemical Name: 
_S_(+)-1-[3-(dimethylamino)propyl]-1-(4-flurophenyl)-1,3-dihydroisobenzofuran-5-
carbonitrile hydrogen oxalate 

Structural Formula: 

Molecular Formula: 
C
20
H
21
FN
2
O, C
2
H
2
O
4

Molecular Weight: 
414.42 

CAS Registry Number: 
219861-08-2 

DESCRIPTION 
Escitalopram is the active enantiomer (_S_-enantiomer) of citalopram. Escitalopram oxalate is a fine white 
to yellow, crystalline material. 

Escitalopram oxalate is sparingly soluble
in water, slightly soluble in acetone, soluble in ethanol and
freely 
soluble in methanol. No polymorphic forms have been detected. 

PHARMACOLOGY 
PHARMACOLOGICAL ACTIONS 
Biochemical and behavioural studies have shown that escitalopram is  a potent inhibitor of serotonin 
(5-HT)-uptake (_in vitro_ IC
50 
2nM). 

The antidepressant action of escitalopram is presumably linked
to the potentiation of serotonergic 
activity in the central nervous system (CNS) resulting
from its inhibitory effect on the reuptake of 5-HT 
from the synaptic cleft. 

Escitalopram is a highly selective Serotonin Reuptake
Inhibitor (SSRI). On the basis of _in vitro_ studies, 
escitalopram had no, or minimal effect on noradrenaline
(NA), dopamine (DA) and gamma 
aminobutyric acid (GABA) uptake. 

In contrast to many tricyclic antidepressants and some of the
SSRIs, escitalopram has no or very low 
affinity for a series of receptors including 5-HT
1A
, 5-HT
2
, DA D
1 
and DA D
2
  receptors, 
a
1
-, 
a
2
-,  
β-adrenoceptors, histamine H
1
, muscarine cholinergic, benzodiazepine, and
opioid receptors. A series 
of functional _in vitro_ tests in isolated
organs as well as functional