Nchi: Kanada
Lugha: Kiingereza
Chanzo: Health Canada
PROPYLTHIOURACIL
PALADIN LABS INC.
H03BA02
PROPYLTHIOURACIL
50MG
TABLET
PROPYLTHIOURACIL 50MG
ORAL
100
Prescription
ANTITHYROID AGENTS
Active ingredient group (AIG) number: 0103603001; AHFS:
CANCELLED POST MARKET
2020-03-05
PRESCRIBING INFORMATION Pr PROPYL-THYRACIL ® (propylthiouracil tablets USP) Thyroid Inhibitor Paladin Labs Inc. Date of Revision: 100 Alexis-Nihon Blvd, Suite 600 April 6, 2020 Saint-Laurent, Quebec, Canada H4M 2P2 Squire Pharmaceuticals Inc.. 611 Control No.: 233767 2 PRESCRIBING INFORMATION Pr PROPYL-THYRACIL ® (propylthiouracil tablets USP) Thyroid Inhibitor ACTION Propylthiouracil affects the synthesis of thyroid hormones by inhibiting the incorporation of iodide into thyroglobulin. It does not inactivate thyroid hormones previously formed or interfere with their release from the gland. Also, depending on the activity of the disease and on whether or not the patient has previously received iodide, the clinical effects will not appear until the stored supply of thyroid hormones has been utilized. Clinical response may be delayed for up to two weeks. Propylthiouracil may also decrease the rate of conversion of T 4 (1-thyroxine) to T 3 (triiodothyronine) in peripheral tissues. Iodide uptake is not decreased by propylthiouracil. In responsive patients, prolonged remission may be obtained only after several months of treatment and may take up to several years. The average duration of treatment is usually one year. Data suggest that stopping therapy as soon as the euthyroid state is attained is as effective in some patients as continuing therapy for a year or longer. 3 INDICATIONS Propylthiouracil is indicated: 1. For the medical management of hyperthyroidism. 2. In conjunction with radioiodine to hasten recovery while awaiting the effects of radiation. 3. For control of thyrotoxicosis prior to surgery. 4. In the management of a thyroid storm in addition to other therapeutic measures. CONTRAINDICATIONS Hypersensitivity or idiosyncratic reaction to propylthiouracil. Nursing mothers. WARNINGS SERIOUS WARNINGS AND PRECAUTIONS Liver toxicity (see Hepatic Function section below) HEPATIC FUNCTION: Liver injury resulting in liver failure, liver transplantation, or death, has been reported with propylthiouracil therapy i Soma hati kamili