PLENDIL TABLET (EXTENDED-RELEASE)

Nchi: Kanada

Lugha: Kiingereza

Chanzo: Health Canada

Viambatanisho vya kazi:

FELODIPINE

Inapatikana kutoka:

GLENWOOD GMBH PHARMAZEUTISCHE ERZEUGNISSE

ATC kanuni:

C08CA02

INN (Jina la Kimataifa):

FELODIPINE

Kipimo:

2.5MG

Dawa fomu:

TABLET (EXTENDED-RELEASE)

Tungo:

FELODIPINE 2.5MG

Njia ya uendeshaji:

ORAL

Vitengo katika mfuko:

90

Dawa ya aina:

Prescription

Eneo la matibabu:

DIHYDROPYRIDINES

Bidhaa muhtasari:

Active ingredient group (AIG) number: 0121733003; AHFS:

Idhini hali ya:

APPROVED

Idhini ya tarehe:

2000-02-03

Tabia za bidhaa

PRODUCT MONOGRAPH
PLENDIL
®
Felodipine Extended Release Tablets
2.5 mg, 5 mg and 10 mg felodipine
Antihypertensive Agent
Glenwood GmbH
Pharmazeutische Erzeugnisse
Arabellastr. 17
81925 Munich
Germany
Imported by:
McKesson Specialized Distribution Inc.
8449 Lawson Rd, Unit 102
Milton, Ontario L9T 9L1
Control Number: 278992
Date of Preparation:
February 3, 2000
Date
of Revision:
OCT
17, 2023
- 2 -
PRODUCT MONOGRAPH
NAME OF DRUG
PLENDIL
®
Felodipine Extended Release Tablets
2.5 mg, 5 mg and 10 mg felodipine
THERAPEUTIC CLASSIFICATION
Antihypertensive Agent
ACTIONS AND CLINICAL PHARMACOLOGY
PLENDIL (felodipine) is a calcium ion influx inhibitor (calcium
channel blocker). Felodipine
is a member of the dihydropyridine class of calcium channel blockers.
MECHANISM OF ACTION
The therapeutic effect of this group of drugs is believed to be
related to their specific cellular
action of selectively inhibiting transmembrane influx of calcium ions
into cardiac muscle and
vascular smooth muscle. The contractile processes of these tissues are
dependent upon the
movement of extracellular calcium into the cells through specific ion
channels. Felodipine
blocks transmembrane influx of calcium through the slow channel
without affecting to any
significant degree the transmembrane influx of sodium through the fast
channel. This results
in a reduction of free calcium ions available within cells of the
above tissues.
Felodipine does not alter total serum calcium. _In vitro_ studies show
that the effects of
felodipine on contractile mechanisms are selective, with greater
effects on vascular smooth
muscle than on cardiac muscle. Negative inotropic effects can be
detected _in vitro_, but such
effects have not been seen in intact animals.
The effect of felodipine on blood pressure in man is principally a
consequence of a dose-
related decrease in peripheral vascular resistance, with a modest
reflex increase in heart rate
(see ACTION AND CLINICAL PHARMACOLOGY - Pharmacodynamics).
PHARMACOKINETICS
Felodipine is completely absorbed from the gas