Piportil depot

Nchi: Nyuzilandi

Lugha: Kiingereza

Chanzo: Medsafe (Medicines Safety Authority)

Viambatanisho vya kazi:

Pipotiazine palmitate 50 mg/mL;  

Inapatikana kutoka:

sanofi-aventis new zealand limited

INN (Jina la Kimataifa):

Pipotiazine palmitate 50 mg/mL

Kipimo:

50 mg/mL

Dawa fomu:

Solution for injection

Tungo:

Active: Pipotiazine palmitate 50 mg/mL   Excipient: Nitrogen Sesame oil

Vitengo katika mfuko:

Ampoule, 1ml in 20ml ampoule ex Anagni, 10 dose units

Darasa:

Prescription

Dawa ya aina:

Prescription

Viwandani na:

Somet

Matibabu dalili:

PIPORTIL DEPOT is a long-acting phenothiazine neuroleptic indicated for the maintenance treatment of schizophrenia and paranoid psychoses, and prevention of relapse, especially where compliance with oral medication is a problem.

Bidhaa muhtasari:

Package - Contents - Shelf Life: Ampoule, 1ml in 20ml ampoule ex Anagni - 10 dose units - 60 months from date of manufacture stored at or below 25°C - Ampoule, 2ml in 20ml ampoule - 10 dose units - 60 months from date of manufacture stored at or below 25°C - Ampoule, 1ml in 10ml ampoule ex Dagenham - 10 dose units - 60 months from date of manufacture stored at or below 25°C

Idhini ya tarehe:

1977-08-15

Tabia za bidhaa

piportil-ccsiv1-dsv7-18jan17
1
DATASHEET
PIPORTIL
_ _
NAME OF THE MEDICINE
Pipothiazine palmitate 50 mg/ml injection
PRESENTATION
Injection (in sesame oil) 50 mg/ml; straw-coloured viscous liquid.
USES
_ACTIONS _
Pipothiazine palmitate is an oil-soluble ester of pipothiazine, a
piperidine-type
phenothiazine. The esterification of pipothiazine is responsible for
its prolonged
duration of action on deep intramuscular injection there is slow
diffusion of the ester
from the oily depot into tissue where it is hydrolysed to the active
parent drug,
pipothiazine.
PIPORTIL DEPOT possesses a wide range of antipsychotic activity, a
weak sedative
action, a high degree of tolerance, and an average duration of action
of 4 weeks. It
has a potent activity against the major symptoms of chronic
schizophrenia such as
hallucinations and delusions, and is also effective against negative
symptoms such
as emotional withdrawal, unco-operativeness and other residual
symptoms which
interfere with social integration.
The onset of action appears usually within 2 to 3 days after injection
and the effects
of the medicine on psychotic symptoms may be noted within 2 weeks.
Improvement
in symptomatology lasts from 3 to 6 weeks, but adequate control is
frequently
maintained with one injection every 4 weeks. However, in view of the
variations in
individual response, careful supervision is required throughout
treatment.
_ _
_PHARMACOKINETICS _
There is little information about blood levels, distribution and
excretion in humans.
The rate of metabolism and excretion of phenothiazines decreases in
old age.
INDICATIONS
PIPORTIL DEPOT is a long-acting phenothiazine neuroleptic indicated
for the
maintenance treatment of schizophrenia and paranoid psychoses, and
prevention of
relapse, especially where compliance with oral medication is a
problem.
CONTRAINDICATIONS
PIPORTIL DEPOT should not be administered to patients in comatose
states or with
marked cerebral atherosclerosis, phaeochromocytoma, renal or liver
failure, severe
cardiac insufficiency or hyper