PERINDOPRIL-LUPIN

Nchi: Australia

Lugha: Kiingereza

Chanzo: Department of Health (Therapeutic Goods Administration)

Viambatanisho vya kazi:

Perindopril erbumine

Inapatikana kutoka:

Lupin Australia Pty Limited

Darasa:

Medicine Registered

Taarifa za kipeperushi

PERINDOPRIL-LUPIN TABLETS

(LUPIN AUSTRALIA PTY. LTD.)

NAME OF MEDICINE 

Perindopril-Lupin
Tablets (Perindopril erbumine 2 mg, 4 mg and 8 mg tablets) 

 DESCRIPTION 

Perindopril erbumine is chemically described
as tert-butylammonium (2S, 3aS, 7aS) 1 - N [ (S) -
1-  ethoxycarbonyl butyl]-L-  alanyl) perhydroindole-2  –  carboxylate.
 Perindopril  is a dipeptide 
monoacid monoester with a perhydroindole group and no
sulphydryl  radical. Perindopril 
erbumine  is a white powder, readily soluble in purified
water, 95% ethanol and chloroform. 
Perindopril erbumine has five asymmetric centres. The
drug is synthesised stereoselectively so 
that it is a single enantiomer (all S stereochemistry).  

CAS Registry Number: 107133-36-8 
Molecular formula:   C
19
H
32
N
2
O
5,
 C
4
H
11
N 
_ _
Chemical structure:  

_ _

Excipients: Lactose, microcrystalline
cellulose, magnesium stearate and silica dimethyl silylate. 

PHARMACOLOGY 

Perindopril (prodrug), following hydrolysis to
perindoprilat, inhibits angiotensin converting 
enzyme (ACE) both in vitro and in
vivo. It is thought that ACE inhibitors reduce blood
pressure 
by inhibiting the enzyme which catalyses the conversion
of angiotensin I to angiotensin II. 
Decreased plasma angiotensin II leads to increased plasma renin
activity and a decrease in 
aldosterone. In addition to its effects on
circulating ACE, perindopril binds to and inhibits tissue 
converting enzyme, predominantly in the
kidney and vascular wall. The contribution of this 
mechanism to the overall antihypertensive effect
of perindopril is unknown. Animal studies have 
demonstrated reversal of vascular hypertrophy and an
improvement in the ratio of elastin to 
collagen in the vessel wall. Studies in man have demonstrated an
improvement in the visco-
elastic properties of large vessels and in
comp