Nchi: Marekani
Lugha: Kiingereza
Chanzo: NLM (National Library of Medicine)
Triamcinolone Acetonide (UNII: F446C597KA) (Triamcinolone - UNII:1ZK20VI6TY)
Arbor Pharmaceuticals, Inc.
Triamcinolone Acetonide
Triamcinolone Acetonide 1 mg in 1 g
TOPICAL
PRESCRIPTION DRUG
Triamcinolone acetonide cream is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components in the preparation.
Triamcinolone Acetonide Cream USP, 0.1% in 30 g (NDC 24338-416-30) tube. Store at controlled room temperature 20° to 25°C (68° to 77°F). Avoid freezing.
Abbreviated New Drug Application
PEDIADERM TA- TRIAMCINOLONE ACETONIDE CREAM ARBOR PHARMACEUTICALS, INC. ---------- TRIAMCINOLONE ACETONIDE CREAM USP, 0.1% RX ONLY DESCRIPTION The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. The steroids in this class include Triamcinolone Acetonide. Triamcinolone Acetonide is designated chemically as 9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20- dione cyclic 16,17-acetal with acetone. With the molecular formula of C H FO and a molecular weight of 434.51. The structural formula is: Each gram of Triamcinolone Acetonide Cream USP, 0.1% contains 1 mg Triamcinolone Acetonide in a cream base consisting of cetyl alcohol, cetyl esters wax, glyceryl monostearate, isopropyl palmitate, polysorbate-60, polysorbate-80, propylene glycol and purified water. CLINICAL PHARMACOLOGY Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man. PHARMACOKINETICS The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses (See DOSAGE AND ADMINISTRATION). Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways Soma hati kamili