Nchi: Marekani
Lugha: Kiingereza
Chanzo: NLM (National Library of Medicine)
NEOMYCIN SULFATE (UNII: 057Y626693) (NEOMYCIN - UNII:I16QD7X297), POLYMYXIN B SULFATE (UNII: 19371312D4) (POLYMYXIN B - UNII:J2VZ07J96K), BACITRACIN ZINC (UNII: 89Y4M234ES) (BACITRACIN - UNII:58H6RWO52I)
Putney, Inc.
NEOMYCIN SULFATE
NEOMYCIN 3.5 mg in 1 g
OPHTHALMIC
PRESCRIPTION DRUG
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis, and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment is contraindicated in individuals who have shown hypersensitivity to any of its components.
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment USP is supplied in 3.5 g (1/8 oz) sterile tamper evident tubes with ophthalmic tip. NDC 26637-841-41 Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature]. Manufactured for: Putney, Inc. Portland, ME 04101 USA 1-866-683-0660 PUTNEY Rev. April 2015 8T900 L7 J1 Ini0215
Abbreviated New Drug Application
NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC- NEOMYCIN SULFATE, POLYMYXIN B SULFATE, BACITRACIN ZINC OINTMENT PUTNEY, INC. ---------- NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC OPHTHALMIC OINTMENT USP STERILE RX ONLY DESCRIPTION: Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment is a sterile antimicrobial ointment for ophthalmic use. Each gram contains: neomycin sulfate equivalent to 3.5 mg neomycin base, polymyxin B sulfate equivalent to 10,000 polymyxin B units, bacitracin zinc equivalent to 400 bacitracin units in a white petrolatum and mineral oil base. Neomycin sulfate is the sulfate salt of neomycin B and C, which are produced by the growth of _Streptomyces fradiae_ Waksman (Fam. _Streptomycetaceae_). It has a potency equivalent of not less than 600 μg of neomycin standard per mg, calculated on an anhydrous basis. The structural formulae are: Polymyxin B sulfate is the sulfate salt of polymyxin B and B , which are produced by the growth of _Bacillus polymyxa_ (Prazmowski) Migula (Fam. _Bacillaceae_). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are: 1 2 Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the _licheniformis_ group of _Bacillus subtilis _var Tracy. It has a potency of not less than 40 bacitracin units per mg. The structural formula is: CLINICAL PHARMACOLOGY: A wide range of antibacterial action is provided by the overlapping spectra of neomycin, polymyxin B sulfate, and bacitracin. Neomycin is bactericidal for many gram-positive and gram-negative organisms. It is an aminoglycoside antibiotic which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code. Polymyxin B is bactericidal for a variety of gram-negative organisms. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid c Soma hati kamili