Nchi: Kanada
Lugha: Kiingereza
Chanzo: Health Canada
METHOTREXATE (METHOTREXATE SODIUM)
MEDEXUS PHARMACEUTICALS INC.
L01BA01
METHOTREXATE
20MG
SOLUTION
METHOTREXATE (METHOTREXATE SODIUM) 20MG
INTRA-ARTERIAL
2ML
Prescription
ANTINEOPLASTIC AGENTS
Active ingredient group (AIG) number: 0107545004; AHFS:
CANCELLED POST MARKET
2017-05-19
PRODUCT MONOGRAPH Pr METOJECT ® methotrexate sodium Solution for Injection 10 mg/mL Single-Use Pre-Filled Syringes Sterile THERAPEUTIC CLASSIFICATION Antimetabolite and Antirheumatic Medexus Inc. DATE OF PREPARATION : 7895 Tranmere Drive, Unit 4 JANUARY 08, 2008 Mississauga, Ontario L5S 1V9 CONTROL NUMBER: 107035 2 Pr METOJECT ® methotrexate sodium Solution for Injection 10 mg/mL Single-Use Pre-Filled Syringes Sterile THERAPEUTIC CLASSIFICATION Antimetabolite and Antirheumatic CAUTION METOJECT (METHOTREXATE SODIUM) SHOULD BE USED ONLY BY PHYSICIANS WHOSE KNOWLEDGE AND EXPERIENCE INCLUDES THE USE OF ANTIMETABOLITE THERAPY . ACTIONS AND CLINICAL PHARMACOLOGY Methotrexate is a folate antagonist. Methotrexate inhibits dihydrofolate reductase (DHFR), the enzyme that reduces folic acid to tetrahydrofolic acid. Tetrahydrofolate must be regenerated via the DHFR-catalyzed reaction in order to maintain the intracellular pool of tetrahydrofolate one-carbon derivatives for both thymidylate and purine nucleotide biosynthesis. The inhibition of DHFR by folate antagonists (Methotrexate) results in a deficiency in the cellular pools of thymidylate and purines and thus in a decrease in nucleic acid synthesis. Therefore, methotrexate interferes with DNA synthesis, repair, and cellular replication. Methotrexate is most active against rapidly multiplying cells, because its cytotoxic effects occur primarily during the S phase of the cell cycle. Since cellular proliferation in malignant tissues is 3 greater than in most normal tissues, methotrexate may impair malignant growth without irreversible damage to normal tissues. As a result, actively proliferating tissues such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and cells of the urinary bladder are in general more sensitive to DHFR inhibition effects of methotrexate. The cytotoxicity of methotrexate results from three important actions: inhibition of DHFR, inhibition of thymidylate synthase, and alteration of the transport of reduced folates. The aff Soma hati kamili