LYCINATE glyceryl trinitrate 600microgram tablet bottle

Nchi: Australia

Lugha: Kiingereza

Chanzo: Department of Health (Therapeutic Goods Administration)

Viambatanisho vya kazi:

glyceryl trinitrate

Inapatikana kutoka:

Arrow Pharma Pty Ltd

INN (Jina la Kimataifa):

glyceryl trinitrate

Idhini hali ya:

Registered

Taarifa za kipeperushi

LYCINATE
®
- Consumer Medicine Information
Page 1 of 5
LYCINATE
® TABLETS
glyceryl trinitrate
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about LYCINATE. It does
not contain all of the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking LYCINATE
against the benefits this medicine is
expected to have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT LYCINATE IS USED
FOR
LYCINATE is used for angina.
Angina is a pain or discomfort in the
chest, often spreading to the arms or
neck and sometimes to the
shoulders and back. This is usually
caused by too little blood and oxygen
getting to the heart muscle. The pain
of angina is usually brought on by
exercise or stress. Other factors
may also cause angina. LYCINATE
is used to treat an angina attack or to
prevent one developing.
LYCINATE belongs to a group of
medicines called nitrates. It lets
more blood and oxygen reach the
heart muscle.
Your doctor may have prescribed this
medicine for another reason.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY LYCINATE
HAS BEEN PRESCRIBED FOR YOU.
There is no evidence that LYCINATE
is addictive or habit forming.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT _
DO NOT TAKE LYCINATE IF YOU HAVE
EVER HAD AN ALLERGIC REACTION TO:
•
glyceryl trinitrate, the active
ingredient in LYCINATE.
•
other medicines containing
glyceryl trinitrate-
For example skin patches (such
as Deponit, Minitran, Nitradisc,
Nitro-Dur, Transiderm-Nitro), and
sprays (such as Nitrolingual
Spray).
•
any medicine or food containing
nitrates or nitrites.
•
any of the ingredients listed at the
end of this leaflet.
Symptoms of an allergic reaction
may be mild or severe. They usually
include some or all of the following:
•
asthma, wheezing or shortness
of breat

Tabia za bidhaa

LYCINATE- Product Information
Page 1 of 5
PRODUCT INFORMATION
NAME OF THE MEDICINE
LYCINATE
tablets contain
glyceryl trinitrate
.
DESCRIPTION
Glyceryl trinitrate is a white to pale yellow, thick, flammable,
explosive liquid. It is slightly soluble in
water (0.1% to 1% w/v) and soluble in acetone, alcohol, and ether.
Glyceryl trinitrate has the
following chemical structure:
The molecular formula of Glyceryl Trinitrate is C
3
H
5
(O.NO
2
)
3
and it has a molecular mass of 227.1
(_CAS _– 55 – 63 – 0)
EXCIPIENTS:
lactose, dextrin, maize starch, mannitol, glycerol, and magnesium
stearate.
PHARMACOLOGY
ACTIONS
LYCINATE is a vasodilator, which relieves angina pectoris. Pain in
angina pectoris is believed to be
the result of myocardial ischaemia secondary to coronary artery
disease. In the relief of acute
anginal pain the effect is apparent after 2 to 3 minutes and lasts for
up to 20 or 30 minutes.
LYCINATE redistributes blood flow along collateral channels and from
epicardial to endocardial
regions and thus may increase blood flow to ischaemic areas. LYCINATE
also reduces oxygen
demand by increasing venous capacitance causing pooling of blood in
the peripheral veins and
thereby reducing ventricular volume. Furthermore, the fall in arterial
pressure will also reduce
myocardial oxygen demand, although this may be offset by a reflex
tachycardia. The beneficial
effects of nitrates in pulmonary oedema depend on venous dilation and
reduction of pre-load.
LYCINATE causes coronary vasodilation in coronary arteries that are in
spasm, and may relieve
pain in variant angina by this mechanism.
LYCINATE is thought to exert its vasodilator effect through the
activation of guanylate cyclase in
vascular smooth muscle cells by nitric oxide; this results in an
increased synthesis of cyclic
guanosine monophosphate, which leads to smooth muscle relaxation.
PHARMACOKINETICS
ABSORPTION:
Glyceryl trinitrate is readily absorbed through the buccal mucosa but
is rapidly metabolised so it has
a fleeting duration of action. Peak plasma level