Nchi: Malesia
Lugha: Kiingereza
Chanzo: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ISOSORBIDE DINITRATE
AVERROES PHARMACEUTICALS SDN. BHD.
ISOSORBIDE DINITRATE
100tablet Tablets; 1000tablet Tablets
Maple Pharmaceuticals (Pvt.) Limited
ISDIN TABLET 10 MG ISOSORBIDE DINITRATE 10 MG DESCRIPTION White round tablet mark maple leaf on one side and ISDIN and bisected line on the other size. COMPOSITION Each Tablet contains Isosorbide Dinitrate 10mg. MODE OF ACTION Isosorbide dinitrate is a vasodilator. SUMMARY OF PHARMACODYNAMICS AND PHARMACOKINETICS Isosorbide dinitrate is readily absorbed from the oral mucosa and also following oral administration. It undergoes extensive first pass metabolism, mainly in the liver. The major metabolites are isosorbide 2-mononitrate and isosorbide 5-mononitrate which both possess vasodilatory activity and may contribute to the activity of the parent compound. INDICATIONS Isosorbide dinitrate taken orally is used in the prophylaxis of angina pectoris and as adjunctive therapy in congestive heart failure. ADVERSE REACTIONS/SIDE EFFECTS As with nitroglycerin and other nitrates, vascular headache occurs and it may be severe and persistent. This adverse effect occurs most frequently at the beginning of therapy. Headache usually can be controlled by temporary dosage reduction, concomitant administration of commonly used analgesics or by administering the drug during meals. These headaches usually disappear within one week of continous, uninterrupted therapy. It is usually best to advise the patient of their possible occurrence and of their importance in regard to the prevention of angina. Drug and/or exfoliative dermatitis occasionally occur. Signs of cerebral ischemia associated with postural hypotension such as weakness or transient episodes of dizziness may occasionally develop. Cutaneous vasodilatation with flushing may occur. Rarely a marked sensitivity to the hypotensive effects of the drug and severe response (nausea, vomiting, restlessness, perspiration and collapse) can occur and alcohol may enhance this effect. Isosorbide dinitrate can antagonize the effects of histamine or epinephrine, acetylcholine and similar agents. PRECAUTION/WARNINGS Development of tolerance may occur with all forms of nitrate therapy parti Soma hati kamili