GLYCOPYRROLATE tablet

Nchi: Marekani

Lugha: Kiingereza

Chanzo: NLM (National Library of Medicine)

Viambatanisho vya kazi:

GLYCOPYRROLATE (UNII: V92SO9WP2I) (GLYCOPYRRONIUM - UNII:A14FB57V1D)

Inapatikana kutoka:

Avera McKennan Hospital

INN (Jina la Kimataifa):

GLYCOPYRROLATE

Tungo:

GLYCOPYRROLATE 1 mg

Dawa ya aina:

PRESCRIPTION DRUG

Idhini hali ya:

Abbreviated New Drug Application

Tabia za bidhaa

GLYCOPYRROLATE- GLYCOPYRROLATE TABLET
AVERA MCKENNAN HOSPITAL
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GLYCOPYRROLATE TABLETS, USP
RX ONLY
DESCRIPTION
Glycopyrrolate Tablets, USP contain the synthetic anticholinergic,
glycopyrrolate. Glycopyrrolate is a
quaternary ammonium compound with the following chemical name: 3-
[(cyclopentylhydroxyphenylacetyl)oxy]-1, 1-dimethylpyrrolidinium
bromide. The structural formula of
Glycopyrrolate is represented below: Glycopyrrolate is supplied as 1
mg and 2 mg tablets.
INACTIVE INGREDIENTS:
dibasic calcium phosphate, lactose monohydrate, magnesium stearate,
microcrystalline cellulose, and
sodium starch glycolate
CLINICAL PHARMACOLOGY
Glycopyrrolate, like other anticholinergic (antimuscarinic) agents,
inhibits the action of acetylcholine
on structures innervated by postganglionic cholinergic nerves and on
smooth muscles that respond to
acetylcholine but lack cholinergic innervation. These peripheral
cholinergic receptors are present in
the autonomic effector cells of smooth muscle, cardiac muscle, the
sino-atrial node, the atrioventricular
node, exocrine glands, and, to a limited degree, in the autonomic
ganglia. Thus, it diminishes the volume
and free acidity of gastric secretions and controls excessive
pharyngeal, tracheal, and bronchial
secretions.
Glycopyrrolate antagonizes muscarinic symptoms (e.g., bronchorrhea,
bronchospasm, bradycardia, and
intestinal hypermotility) induced by cholinergic drugs such as the
anticholinesterases.
The highly polar quaternary ammonium group of glycopyrrolate limits
its passage across lipid
membranes, such as the blood-brain barrier, in contrast to atropine
sulfate and scopolamine
hydrobromide, which are non-polar tertiary amines which penetrate
lipid barriers easily.
INDICATIONS AND USAGE
For use as adjunctive therapy in the treatment of peptic ulcer.
CONTRAINDICATIONS
Glaucoma; obstructive uropathy (for example, bladder neck obstruction
due to prostatic hypertrophy);
obstructive disease of the gastrointestinal tract (as in achalasia,
pyloroduodenal stenosis, etc.); paral