Chemmart Sertraline

Nchi: Australia

Lugha: Kiingereza

Chanzo: Department of Health (Therapeutic Goods Administration)

Viambatanisho vya kazi:

Sertraline hydrochloride

Inapatikana kutoka:

Apotex Pty Ltd

Darasa:

Medicine Registered

Taarifa za kipeperushi

CHEMMART SERTRALINE

_Contains the active ingredient sertraline (as sertraline
hydrochloride)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about sertraline. It does not
contain all the available information.
It does not take the place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is
Chemmart Sertraline. It contains the
active ingredient sertraline (as
sertraline hydrochloride).
It is used to treat:
•
depression
•
social anxiety disorder or social
phobia
•
Pre-Menstrual Dysphoric
Disorder (PMDD)
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Sertraline belongs to a group of
medicines called Selective Serotonin
Re-uptake Inhibitors (SSRIs).
Serotonin is one of the chemicals in
your brain which helps control your
mood. Sertraline and other SSRIs are
thought to help by increasing the
amount of serotonin in your brain.
Depression is longer lasting and/or
more severe than the "low moods"
everyone has from time to time due
to the stress of everyday life. It is
thought to be caused by a chemical
imbalance in parts of

Tabia za bidhaa

Product Information – Australia 
Chemmart Sertraline Tablets 
Page 1 
CHEMMART SERTRALINE TABLETS 

NAME OF THE MEDICINE 
Sertraline hydrochloride. 

Chemical Name:  
(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-
naphthalenamine hydrochloride. 

Structural Formula: 

Molecular Formula:  
C
17
H
17
Cl
2
N.HCl  

Molecular Weight:  
342.7 

CAS Registry Number:  
79559-97-0 

DESCRIPTION 
Sertraline hydrochloride is a white to off-white crystalline
powder that is slightly soluble in water and 
isopropyl alcohol and sparingly soluble in ethanol and
dimethylformamide. 

Sertraline hydrochloride is a Selective Serotonin Re-uptake
Inhibitor (SSRI) antidepressant for oral 
administration. It is chemically unrelated to
tricyclic, tetracyclic or other available
antidepressant agents. 

Sertraline is a disubstituted
tetrahydronaphthalene with two asymmetric centres and can
exist as four 
enantiomeric forms in either the
trans- or cis- configuration. The cis-(1S,4S) sertraline
enantiomer is used. 

PHARMACOLOGY 
PHARMACODYNAMICS 
The mechanism of action of sertraline is presumed to be linked
to its inhibition of CNS neuronal uptake of 
serotonin (5HT). Studies at clinically relevant doses in humans have demonstrated that sertraline blocks 
the uptake of serotonin into human platelets. _In vitro_ studies in animals also suggest that sertraline is a 
potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on 
noradrenaline and dopamine
neuronal re-uptake.  _In vitro_  studies have shown
that sertraline has no 
significant affinity to adrenergic (alpha
1
, alpha
2
, beta) cholinergic, GABA, dopaminergic, histaminergic, 
serotonergic (5HT
1A
, 5HT
1B
, 5HT
2
) or benzodiazepine receptors; antagonism of such receptors h