Nchi: Australia
Lugha: Kiingereza
Chanzo: Department of Health (Therapeutic Goods Administration)
lisinopril dihydrate
Apotex Pty Ltd
Lisinopril dihydrate
Registered
CHEMMART LISINOPRIL TABLETS _Contains the active ingredient lisinopril (as lisinopril dihydrate)_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about lisinopril. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Chemmart Lisinopril. It contains the active ingredient lisinopril (as lisinopril dihydrate). It is used to treat the following: • People with mild or moderate hypertension (high blood pressure) • People with congestive heart failure • People with acute myocardial infarction (heart attack) HIGH BLOOD PRESSURE Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed. People with high blood pressure often feel fine and have no symptoms. You can only tell if you have high blood pressure by having your blood pressure regularly checked. If hi Soma hati kamili
Product Information – Australia Chemmart Lisinopril Tablets Page 1 CHEMMART LISINOPRIL TABLETS NAME OF THE MEDICINE Lisinopril dihydrate. Chemical Name: _N_-[_N_-[(1_S_)-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dehydrate. Structural Formula: _ _ _ _ _ _ Molecular Formula: C 21 H 31 N 3 O 5 .2H 2 O Molecular Weight: 441.53 CAS Registry Number: 83915-83-7 DESCRIPTION Lisinopril dihydrate is a white to off-white crystalline powder that is soluble in water, sparingly soluble in methanol and practically insoluble in ethanol. Each tablet contains lisinopril dihydrate as the active ingredient. In addition, each tablet contains the following inactive ingredients: calcium hydrogen phosphate, Mannitol, maize starch, magnesium stearate and iron oxide red (C177491). PHARMACOLOGY A synthetic peptide derivative, lisinopril dihydrate is an oral long-acting angiotensin converting enzyme inhibitor. It is a lysine analogue of enalaprilat (active metabolite of enalapril). MECHANISM OF ACTION Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor substance, angiotensin ll. Angiotensin ll also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of plasma angiotensin ll which results in decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase of serum potassium. In hypertensive patients with normal renal function treated with lisinopril alone for up to 24 weeks, the mean increase in serum potassium was approximately 0.1 mmol/L; however, approximately 15% of patients had increases greater than 0.5 mmol/L and approximately 6% had a decrease greater than 0.5 mmol/L. In the same study, patients treated with lisinopril and hydrochlorothiazide for up to 24 weeks had a mean decrease in serum potassium of 0.1 mmol/L; approximately 4% of patients had increases greater than 0.5 mmol/L and approximately 12 Soma hati kamili