Nchi: Malesia
Lugha: Kiingereza
Chanzo: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol; ORPHENADRINE CITRATE
DUOPHARMA (M) SDN. BHD.
Paracetamol; ORPHENADRINE CITRATE
120 Tablets
DUOPHARMA (M) SDN. BHD.
Not Applicable Soma hati kamili
[DUOPHARMA (M) SDN BHD] C E T A G E S I C TABLET DESCRIPTION: An oblong, scored tablet, green in color with markings ‘dp 500’ and ‘duo / duo’. COMPOSITION: Each tablet contains: Paracetamol …………… 500 mg Orphenadrine Citrate…….. 25 mg PHARMACODYNAMIC: Orphenadrine is a skeletal muscle relaxant. Paracetamol is an analgesic and antipyretic. PHARMACOKINETIC: Orphenadrine is readily absorbed from the gastrointestinal tract and is almost completely metabolized to at least 8 metabolites. It is mainly excreted in the urine as metabolites and small amounts of unchanged drug. Paracetamol is readily absorbed from the gastro intestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral administration. Paracetamol is distributed into most body tissues. It crosses the placenta and is present in breast milk. Plasma-protein binding is negligible at usual therapeutic concentrations but increases with increasing concentrations. The elimination half-life of paracetamol varies from about 1 to 3 hours. Paracetamol is metabolized predominantly in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged paracetamol. A minor hydroxylated metabolite (_N-_acetyl-_p-_benzoquinoneimine) which is usually produced in very small amounts by mixed-function oxidases in the liver and kidney and which is usually detoxified by conjugation with glutathione may accumulate following paracetamol overdosage and cause tissue damage. INDICATIONS: Tension headache, occipital headaches associated with spasm of skeletal muscles in the region of the head and neck. Acute and traumatic conditions of the limbs and trunk; sprains, strains, whiplash injuries, acute torticollis, prolapsed intervertebral disc. RECOMMENDED DOSAGE: Two tablets three times daily. ROUTE OF ADMINISTRATION: To be taken orally only. CONTRAINDICATIONS: Orphenadrine shows some anticholinergic activity and should not be used in patients with glaucoma, prostatic hypertrophy o Soma hati kamili