Nchi: Malesia
Lugha: Kiingereza
Chanzo: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CARBIDOPA; ENTACAPONE; LEVODOPA
LABORATORIES TORRENT (MALAYSIA) SDN. BHD.
CARBIDOPA; ENTACAPONE; LEVODOPA
30 Tablets; 10 Tablets
TORRENT PHARMACEUTICAL LIMITED
CELTOR TABLETS _ _ Levodopa, Carbidopa and Entacapone (50mg + 12.5mg + 200mg, 100mg + 25mg + 200mg) _ _ _ _ 1 _ CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What is CELTOR used for 2. How CELTOR works 3. Before you use CELTOR 4. How to use CELTOR 5. While you are using it 6. Side effects 7. Storage and Disposal of CELTOR 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT CELTOR IS USED FOR It is used for the treatment of Parkinson’s disease. HOW CELTOR WORKS Parkinson’s disease is caused by low levels of a substance called dopamine in the brain. Levodopa increases the amount of dopamine and hence reduces the symptoms of Parkinson’s disease. Carbidopa and Entacapone improve the anti-Parkinson effects of Levodopa. BEFORE YOU USE CELTOR - _When you must not use it _ Do not take CELTOR: If you are allergic to levodopa, carbidopa or entacapone, or any of the other ingredients of this medicine. If you have narrow-angle glaucoma (an eye disorder). If you have a tumour of the adrenal gland. If you are taking certain medicines for treating depression (combinations of selective MAO-A and MAO-B inhibitors or non- selective MAO-inhibitors). If you have ever had neuroleptic malignant syndrome (NMS - this is a rare reaction to medicines used to treat severe mental disorders). If you have ever had non-traumatic rhabdomyolysis (a rare muscle disorder). If you have a severe liver disease. _Pregnancy and lactation_ _ _ Do not take CELTOR if you are pregnant or plan to become pregnant or think you might be pregnant. Do not take CELTOR if you are breast- feeding. Ask your doctor or pharmacist for advice before taking any medicine. - _Before you start use it _ Talk to your doctor before taking CELTOR if you suffer from or you ever 3had:- A heart attack or any other diseases of the heart including cardiac arrhythmias (irregular heartbeat), or of the blood vessels. A liver problem, because your dose may need to be adju Soma hati kamili
CELTOR TABLETS (LEVODOPA, CARBIDOPA AND ENTACAPONE TABLETS 50MG + 12.5MG + 200MG/ 100MG + 25MG + 200MG) BRAND OR PRODUCT NAME CELTOR TABLETS 50+12.5+200mg/100+25+200 mg NAME AND STRENGTH OF ACTIVE SUBSTANCE(S) CELTOR TABLETS 50+12.5+200 MG Each film-coated tablet contains: Levodopa USP .......................... 50mg Carbidopa USP ......................... 12.5mg Entacapone USP ........................ 200mg CELTOR TABLETS 100+25+200 MG Each film-coated tablet contains: Levodopa USP .......................... 100mg Carbidopa USP ...........................25mg Entacapone USP ........................ 200mg PRODUCT DESCRIPTION CELTOR TABLETS 50+12.5+200 MG Light brown to grayish red colored, round, biconvex, film coated tablets with debossed "50" on one side and plain on other side. CELTOR TABLETS 100+25+200 MG Light brown to grayish red colored, oval shaped, film coated tablets with debossed "100" on one side and plain on other side. DOSAGE FORM Film coated bilayered tablet PHARMACODYNAMICS According to the current understanding, the symptoms of Parkinson's disease are related to depletion of dopamine in the corpus striatum. Dopamine does not cross the blood-brain barrier. Levodopa, the precursor of dopamine, crosses the blood brain barrier and relieves the symptoms of the disease. As levodopa is extensively metabolised in the periphery, only a small portion of a given dose reaches the central nervous system when levodopa is administered without metabolic enzyme inhibitors. Carbidopa and benserazide are peripheral (dopa decarboxylase) DDC inhibitors which reduce the peripheral metabolism of levodopa to dopamine, and thus, more levodopa is available to the brain. When decarboxylation of levodopa is reduced with the co- administration of a DDC inhibitor, a lower dose of levodopa can be used and the incidence of adverse reactions such as nausea is reduced. With inhibition of the decarboxylase by a DDC inhibitor, catechol-O-methyltransferase (COMT) becomes the major peripheral metabolic pathway catalyzing the conversi Soma hati kamili