Nchi: Australia
Lugha: Kiingereza
Chanzo: Department of Health (Therapeutic Goods Administration)
candesartan cilexetil, Quantity: 16 mg
Amneal Pharma Australia Pty Ltd
Candesartan cilexetil
Tablet, uncoated
Excipient Ingredients: macrogol 8000; lactose monohydrate; carmellose calcium; magnesium stearate; hyprolose; maize starch; iron oxide red
Oral
30 tablets
(S4) Prescription Only Medicine
Treatment of hypertension.,Treatment of patients with heart failure and impaired left ventricular systolic function (left ventricular ejection fraction <=40percent) as add-on therapy to ACE inhibitors or when ACE inhibitors are not tolerated.
Visual Identification: Light pink, round, biconvex uncoated mottled tablets debossed with L293 on one side and break line on other side.; Container Type: Bottle; Container Material: HDPE; Container Life Time: 12 Months; Container Temperature: Store below 25 degrees Celsius; Container Closure: Child resistant closure
Licence status A
2013-05-02
_Candesartan AN tablets – Consumer Medicine Information _ _ _ _Doc ID: 46.AN.M.1.0 _ _ _ _ _ _Page 1 _ CANDESARTAN AN TABLETS _Candesartan cilexetil _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about CANDESARTAN AN. It does not contain all of the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking CANDESARTAN AN against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT CANDESARTAN AN IS USED FOR CANDESARTAN AN belongs to a group of medicines known as angiotensin-II receptor antagonists. CANDESARTAN AN is used to treat: high blood pressure, also called hypertension heart failure, usually in combination with other medicines. HYPERTENSION Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) which means your blood pressure stays high, even when you are calm and relaxed. Regular blood pressure checks are the only way of knowing that you have hypertension. There are no symptoms of hypertension and you may feel fine. If hypertension is not treated, serious health problems such as stroke or heart attack and heart or kidney failure may occur. CANDESARTAN AN lowers blood pressure by dilating (expanding) small blood vessels from the heart, letting the blood be pumped around the body more easily. HEART FAILURE Heart failure means that the heart muscle cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops working. Heart failure may start off with no symptoms, but as the condition progresses Soma hati kamili
_Candesartan AN tablets Product Information _ _ _ _ Scentia Pharmaceuticals Pty Ltd _ Doc ID: 46.AN.P.1.0 Page 1 CANDESARTAN AN _ _ _(CANDESARTAN CILEXETIL TABLETS) _ _ _ PRODUCT INFORMATION NAME OF THE MEDICINE The name of the medicine is candesartan cilexetil. CHEMICAL NAME: (1_RS_)-1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2′-(1_H_-tetrazol-5- yl)biphenyl-4-yl]methyl]-1_H_-benzimidazole-7-carboxylate MOLECULAR FORMULA: C 33 H 34 N 6 O 6 MOLECULAR WEIGHT: 610.67 CAS REGISTRY NUMBER: 145040-37-5 DESCRIPTION Candesartan cilexetil is a white or almost white powder and is practically insoluble in water, freely soluble in methylene chloride and slightly soluble in anhydrous ethanol. Three polymorphic forms have been identified; crystal form I, crystal form II and an amorphous form. Crystalline form I is used in CANDESARTAN AN. CANDESARTAN AN tablets come in four strengths and contain 4 mg, 8 mg, 16 mg or 32 mg of candesartan cilexetil. The tablets also contain lactose, carmellose calcium, maize starch, macrogol 8000, hydroxypropylcellulose, magnesium stearate and Pigment Blend PB-24880 Pink (ARTG 108327).. The tablets are gluten free. PHARMACOLOGY PHARMACODYNAMICS Angiotensin II is the primary vasoactive hormone of the renin-angiotensin-aldosterone system and plays a significant role in the pathophysiology of hypertension, heart failure and other cardiovascular disorders. It also has an important role in the pathogenesis of end organ hypertrophy and damage. The major physiological effects of angiotensin II, such as vasoconstriction, aldosterone stimulation, _Candesartan AN tablets Product Information _ _ _ _ Scentia Pharmaceuticals Pty Ltd _ Doc ID: 46.AN.P.1.0 Page 2 regulation of salt and water homeostasis and stimulation of cell growth, are mediated via the type 1 (AT 1 ) receptor. Candesartan cilexetil is a prodrug suitable for oral use. It is rapidly converted to the active drug, candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. Candesartan is an angiotensin II recep Soma hati kamili