ANGININE glyceryl trinitrate 600microgram tablet bottle

Nchi: Australia

Lugha: Kiingereza

Chanzo: Department of Health (Therapeutic Goods Administration)

Viambatanisho vya kazi:

glyceryl trinitrate, Quantity: 600 microgram

Inapatikana kutoka:

Arrotex Pharmaceuticals Pty Ltd

INN (Jina la Kimataifa):

glyceryl trinitrate

Dawa fomu:

Tablet, uncoated

Tungo:

Excipient Ingredients: glycerol; magnesium stearate; lactose monohydrate; dextrin; mannitol; pregelatinised maize starch

Njia ya uendeshaji:

Sublingual

Vitengo katika mfuko:

30 tablets, 100 tablets

Dawa ya aina:

(S3) Pharmacist Only Medicine

Matibabu dalili:

Treatment of acute angina pectoris. As well as relieving the pain of an acute attack, it may be used prophylactically before physical exertion or mental stress which would be expected to produce an anginal attack.

Bidhaa muhtasari:

Visual Identification: Small, round white tablets, with break line on one side and plain on the other side; Container Type: Bottle; Container Material: Glass; Container Life Time: 2 Years; Container Temperature: Store below 25 degrees Celsius

Idhini hali ya:

Licence status A

Idhini ya tarehe:

2015-02-19

Taarifa za kipeperushi

ANGININE- Consumer Medicine Information
Page 1 of 5
ANGININE® TABLETS
_glyceryl trinitrate _
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about _Anginine_.
It does not contain all of the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using _Anginine_
against the benefits this medicine
is expected to have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT _ANGININE_ IS USED
FOR
_Anginine _is used for angina.
Angina is a pain or discomfort in
the chest, often spreading to the
arms or neck and sometimes to
the shoulders and back. This is
usually caused by too little blood
and oxygen getting to the heart
muscle. The pain of angina is
usually brought on by exercise or
stress. Other factors may also
cause angina. _Anginine_ is used to
treat an angina attack or to prevent
one developing.
_Anginine_ belongs to a group of
medicines called nitrates. It lets
more blood and oxygen reach the
heart muscle.
Your doctor may have prescribed
_Anginine _for another reason.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you.
There is no evidence that _Anginine _is
addictive or habit forming.
BEFORE YOU USE IT
_WHEN YOU MUST NOT USE IT _
DO NOT USE _ANGININE_ IF YOU HAVE
EVER HAD AN ALLERGIC REACTION TO:
•
GLYCERYL TRINITRATE, THE ACTIVE
INGREDIENT IN _ANGININE._
•
OTHER MEDICINES CONTAINING_ _
GLYCERYL TRINITRATE
For example skin patches (such as
Deponit, Minitran, Nitradisc, Nitro-
Dur, Transiderm-Nitro),_ _and sprays
(such as Nitrolingual Spray).
•
ANY MEDICINE OR FOOD
CONTAINING_ _NITRATES OR NITRITES_. _
•
ANY OF THE INGREDIENTS LISTED AT
THE END OF THIS LEAFLET._ _
Symptoms of an allergic reaction
may be mild or severe. They usually
include some or all of the following:
•
asthma, whee

Tabia za bidhaa

ANGININE- Product Information
Page 1 of 5
ANGININE
PRODUCT INFORMATION
NAME OF THE MEDICINE
ANGININE
tablets contain glyceryl trinitrate.
DESCRIPTION
Glyceryl trinitrate is a white to pale yellow, thick, flammable,
explosive liquid. It is slightly
soluble in water (0.1% to 1% w/v) and soluble in acetone, alcohol, and
ether. Glyceryl trinitrate
has the following chemical structure:
The molecular formula of Glyceryl Trinitrate is C
3
H
5
(O.NO
2
)
3
and it has a molecular mass of
227.1 (_CAS _– 55 – 63 – 0)
EXCIPIENTS: lactose, dextrin, maize starch, mannitol, glycerol, and
magnesium stearate.
PHARMACOLOGY
ACTIONS
ANGININE is a vasodilator which relieves angina pectoris. Pain in
angina pectoris is believed
to be the result of myocardial ischaemia secondary to coronary artery
disease. In the relief of
acute anginal pain the effect is apparent after 2 to 3 minutes and
lasts for up to 20 or 30
minutes.
ANGININE
redistributes
blood
flow
along
collateral
channels
and
from
epicardial
to
endocardial regions and thus may increase blood flow to ischaemic
areas. ANGININE also
reduces oxygen demand by increasing venous capacitance causing pooling
of blood in the
peripheral veins and thereby reducing ventricular volume. Furthermore,
the fall in arterial
pressure will also reduce myocardial oxygen demand, although this may
be offset by a reflex
tachycardia. The beneficial effects of nitrates in pulmonary oedema
depend on venous
dilation and reduction of pre-load. ANGININE causes coronary
vasodilation in coronary
arteries that are in spasm, and may relieve pain in variant angina by
this mechanism.
ANGININE is thought to exert its vasodilator effect through the
activation of guanylate cyclase
in vascular smooth muscle cells by nitric oxide; this results in an
increased synthesis of cyclic
guanosine monophosphate, which leads to smooth muscle relaxation.
O
O
O
NO
2
O
2
N
NO
2
ANGININE- Product Information
Page 2 of 5
PHARMACOKINETICS
ABSORPTION:
Glyceryl trinitrate is readily absorbed through the buccal mucosa but
is rapidly