ACYCLOVIR ointment

Nchi: Marekani

Lugha: Kiingereza

Chanzo: NLM (National Library of Medicine)

Viambatanisho vya kazi:

Acyclovir (UNII: X4HES1O11F) (Acyclovir - UNII:X4HES1O11F)

Inapatikana kutoka:

Taro Pharmaceuticals U.S.A., Inc.

INN (Jina la Kimataifa):

Acyclovir

Tungo:

Acyclovir 50 mg in 1 g

Njia ya uendeshaji:

TOPICAL

Dawa ya aina:

PRESCRIPTION DRUG

Matibabu dalili:

Acyclovir Ointment USP, 5% is indicated in the management of initial genital herpes and in limited non-life-threatening mucocutaneous Herpes simplex virus infections in immunocompromised patients. Acyclovir Ointment USP, 5% is contraindicated in patients who develop hypersensitivity to the components of the formulation.

Bidhaa muhtasari:

Each gram of Acyclovir Ointment USP, 5% contains 50 mg acyclovir in a polyethylene glycol base. Acyclovir Ointment USP, 5% is a smooth, white, cream-like ointment supplied in 15 gram (NDC 51672-1360-1) and 30 gram (NDC 51672-1360-2) tubes. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature] in a dry place .

Idhini hali ya:

Abbreviated New Drug Application

Tabia za bidhaa

ACYCLOVIR- ACYCLOVIR OINTMENT
TARO PHARMACEUTICALS U.S.A., INC.
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ACYCLOVIR
OINTMENT USP, 5%
RX ONLY
PRESCRIBING INFORMATION
ACYCLOVIR OINTMENT USP, 5%
DESCRIPTION
Acyclovir is a synthetic nucleoside analogue active against herpes
viruses. Acyclovir Ointment USP,
5% is a formulation for topical administration. Each gram of Acyclovir
Ointment USP, 5% contains 50
mg of acyclovir in a polyethylene glycol (PEG) base.
Acyclovir is a white to off-white, crystalline powder with the
molecular formula C H N O and a
molecular weight of 225. The maximum solubility in water at 37°C is
2.5 mg/mL. The pka's of acyclovir
are 2.27 and 9.25. The chemical name of acyclovir is
2-amino-1,9-dihydro-9- [(2-
hydroxyethoxy)methyl]-6_H-_purin-6-one; it has the following
structural formula:
VIROLOGY
MECHANISM OF ANTIVIRAL ACTION
Acyclovir is a synthetic purine nucleoside analogue with in vitro and
in vivo inhibitory activity against
herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster
virus (VZV).
The inhibitory activity of acyclovir is highly selective due to its
affinity for the enzyme thymidine
kinase (TK) encoded by HSV and VZV. This viral enzyme converts
acyclovir into acyclovir
monophosphate, a nucleotide analogue. The monophosphate is further
converted into diphosphate by
cellular guanylate kinase and into triphosphate by a number of
cellular enzymes. In vitro, acyclovir
triphosphate stops replication of herpes viral DNA. This is
accomplished in 3 ways: 1) competitive
inhibition of viral DNA polymerase, 2) incorporation into and
termination of the growing viral DNA
chain, and 3) inactivation of the viral DNA polymerase. The greater
antiviral activity of acyclovir
against HSV compared to VZV is due to its more efficient
phosphorylation by the viral TK.
ANTIVIRAL ACTIVITIES
The quantitative relationship between the in vitro susceptibility of
herpes viruses to antivirals and the
8
11
5
3
clinical response to therapy has not been established in humans, and
virus sensitivity testing has not been
standardized.