Zovirax Ophthalmic Ointment

Држава: Аустралија

Језик: Енглески

Извор: Department of Health (Therapeutic Goods Administration)

Активни састојак:

Aciclovir

Доступно од:

GlaxoSmithKline Australia Pty Ltd

Класа:

Medicine Listed (Export Only)

Информативни летак

ZOVIRAX OPHTHALMIC
(EYE) OINTMENT

_Acyclovir_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Zovirax ophthalmic
ointment. It does not contain all the
available information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using Zovirax
ophthalmic ointment against the
benefits they expect it will have for
you.
IF YOU HAVE ANY CONCERNS ABOUT THIS
MEDICINE, ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT ZOVIRAX
OPHTHALMIC OINTMENT
IS USED FOR
Zovirax ophthalmic ointment is used
for the treatment of herpes simplex
virus infections of the eye.
Aciclovir (the active ingredient in
Zovirax ophthalmic ointment)
belongs to a group of medicines
called "anti-virals".
Zovirax ophthalmic ointment works
by stopping the production of the
herpes simplex virus. Zovirax
ophthalmic ointment does not get rid
of the virus from your body.
Zovirax ophthalmic ointment is only
suitable for use in the eye.
Your doctor may have prescribed
Zovirax ophthalmic ointment for
another purpose. Ask your doctor or
pharmacist if you have any questions
about why Zovirax ophthalmic
ointment has been prescribed for you.
There is no evidence that Zovirax
ophthalmic ointment is addictive
This medicine is available only with
a doctor's prescription.
BEFORE YOU USE
ZOVIRAX OPHTHALMIC
OINTMENT
_WHEN YOU MUST NOT USE IT_
DO NOT USE ZOVIRAX OPHTHALMIC
OINTMENT IF:
•
YOU HAVE OR HAVE HAD AN ALLERGY
TO ZOVIRAX, ACICLOVIR,
VALACICLOVIR OR ANY OF THE
INGREDIENTS LISTED AT THE END OF
THIS LEAFLET
DO NOT USE ZOVIRAX OPHTHALMIC
OINTMENT IF THE PACKAGING IS TORN OR
SHOWS SIGNS OF TAMPERING.
DO NOT USE ZOVIRAX OPHTHALMIC
OINTMENT IF THE EXPIRY DATE (EXP)
PRINTED ON THE PACK HAS PASSED.
If you use this medicine after the
expiry date has passed, it may not
work as well.
DO NOT USE ZOVIRAX OPHTHALMIC
OINTMENT 28 DAYS AFTER FIRST
OPENING THE TUBE

Карактеристике производа

1 
PRODUCT INFORMATION 

ZOVIRAX
 OPHTHALMIC OINTMENT 

NAME OF THE MEDICINE:  Aciclovir 

DESCRIPTION: 

Aciclovir is a synthetic acyclic purine nucleoside
analogue. Its chemical name is 
9-((2-hydroxyethoxy)methyl)guanine. It is a white crystalline
powder. Each gram of Zovirax 
Ophthalmic Ointment contains 30 mg of aciclovir in white
soft paraffin base  (aciclovir 3 per 
cent). 

PHARMACOLOGY: 

MICROBIOLOGY: 
Aciclovir is an antiviral agent which is active _in vitro_ against _Herpes simplex_ virus (HSV) types 
I and II.  However, the relationship between _in vitro_  sensitivity of herpes viruses to aciclovir 
and clinical response to therapy has yet to be established.  Aciclovir needs to be 
phosphorylated  to the active
compound, aciclovir triphosphate, in order to become active 
against the virus.  Such conversion is very limited in
normal cells and in addition cellular DNA 
polymerase is not very sensitive to the active compound. 
However, in infected cells HSV or 
VZV-coded thymidine kinase facilitates the conversion of aciclovir to aciclovir monophosphate 
which is then converted to
aciclovir triphosphate by cellular enzymes.  Aciclovir triphosphate 
acts as an inhibitor of, and substrate for, the herpes-specified
DNA polymerase, preventing 
further viral DNA synthesis. 

PHARMACOKINETICS:  
Aciclovir is absorbed through the corneal epithelium and
superficial ocular tissues, and 
achieves significant concentrations in aqueous humour. 
Small quantities (2-16% of the 
applied dose) appear in the urine.  In
animal studies low levels of aciclovir could be detected 
in blood after topical application to the eye. 

INDICATIONS: 

Treatment of _Herpes simplex_ keratitis. 

CONTRAINDICATIONS: 

Patients with known hypersensitivity to
aciclovir or valaciclovir. 

PRECAUTIONS: