TIENAM INJECTION 500MG

Држава: Малезија

Језик: Енглески

Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активни састојак:

IMIPENEM; CILASTATIN SODIUM

Доступно од:

MERCK SHARP & DOHME (MALAYSIA) SDN BHD

INN (Међународно име):

IMIPENEM; CILASTATIN SODIUM

Јединице у пакету:

1Units Units; 0 20 ml 0 mL; 20 ml mL

Произведен од:

Merck Sharp & Dohme LLC

Информативни летак

Not Applicable

Карактеристике производа

TIENAM
LPC-
MK0787B
-IV-032022a
(imipenem and cilastatin sodium, MSD)
LOCAL PRODUCT CIRCULAR
I.V. Infusion
TIENAM
®
(imipenem and cilastatin sodium, MSD)
TIENAM®
(imipenem
and
cilastatin
sodium,
MSD)
is
a
broad-spectrum
beta-lactam
antibiotic supplied as
intravenous
infusion only. TIENAM consists of two
components:
(1)
imipenem, the first of a new class of beta-lactam
antibiotics,
the
thienamycins;
and (2)
cilastatin sodium, a specific enzyme inhibitor that blocks the
metabolism
of imipenem in the
kidney, and
substantially
increases the
concentration
of intact imipenem in the urinary tract.
Imipenem and cilastatin sodium are present in TIENAM in a 1:1 ratio by
weight.
The thienamycin class of
antibiotics,
to which imipenem belongs, is
characterized
by a
spectrum of potent
bactericidal
activity broader than that provided by any other antibiotic
studied.
MICROBIOLOGY
TIENAM is a potent inhibitor of bacterial cell wall synthesis and is
bactericidal
against a
broad spectrum of pathogens
—
gram-
positive and gram
-
negative, aerobic and anaerobic.
TIENAM shares with the newer
cephalosporins
and
penicillins
a broad spectrum of activity
against gram-negative species, but is unique in retaining the high
potency against gram-
positive
species,
previously
associated
only
with
earlier
narrow-spectrum
beta-lactam
antibiotics.
The
spectrum
of
activity
of
TIENAM
includes
Pseudomonas
aeruginosa,
Staphylococcus
aureus,
Enterococcus
faecalis,
and
Bacteroides fragilis
, a diverse group of
problem pathogens commonly resistant to other antibiotics.
TIENAM is resistant to
degradation
by bacterial beta-
lactamases,
which makes it active
against a high percentage of organisms such as
Pseudomonas
aeruginosa, Serratia
spp.,
and
Enterobacter
spp.,
which are inherently resistant to most beta
-
lactam antibiotics.
The
antibacterial
spectrum of TIENAM is broader than that of any other antibiotic
studied
and includes virtually all
clinically
significant pathogens. Organisms against which TIENAM
is usually active
in vitro
include:
GRAM-
NE