SULFABAC 50% POWDER

Држава: Малезија

Језик: Енглески

Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активни састојак:

SULFACHLORPYRIDAZINE SODIUM

Доступно од:

RANGE PHARMA SDN. BHD.

INN (Међународно име):

SULFACHLORPYRIDAZINE SODIUM

Јединице у пакету:

500.00 gm; 25.00 kg; 100.00 gm

Произведен од:

RANGE PHARMA SDN. BHD.

Карактеристике производа

SULFABAC 50% POWDER
DESCRIPTION AND COMPOSITION
SULFABAC 50% POWDER is a light yellowish water soluble powder. Each kg
contains 500g Sulfachlorpyridazine
Sodium as it active ingredient and q.s with lactose.
PHARMACODYNAMICS
Sulfachloropyridazine is in the group of sulfonamides. sulfonamides
are usually bacteriostatic agents when used alone.
They are thought to prevent bacterial replication by competing with
para-aminobenzoic acid (PABA) in the biosynthesis
of tetrahydrofolic acid in the pathway to form folic acid. Only
microorganisms that synthesis their own folic acid are
affected by sulfas.
PHARMACOKINETICS Sulfachlorpyridazine is a broad-spectrum antibacterial compound which
is effective in the treatment of infections caused
by gram-positive and gram-negative organims that are commonly
susceptible to sulfonamide therapy and which has been
proven by laboratory and field experiments to be highly effective
against disease caused by _Escherichia coli_.
Sulfachlorpyridazine has a rapid onset of action in several species of
animals following both oral and parenteral
administration. in comparison with other sulfonamides, the
administration of comparatively effective oral doses of
sulfachlorpyridazine to dogs produces blood concentrations that reach
maximum levels in 1 to 3 hours. The blood level
declines to 1 to 2 mg-percent after 12 hours and the drug is
completely excreted in the urine within 48 hours. In
experimental studies in which cattle are given the recommended dosage
of sulfachlorpyridazine intravenously, the blood
level rises to above 12mg-percent within 1 hour and 6 hours later it
falls to 3 to 4 mg percent; after 18 hours no
sulfonamide can be detected. In swine given the recommended dosage of
sulfachlorpyridazine either intramuscularly or
orally, the blood level reaches 5.5mg percent after 1.5 hours. The
blood level declines to 1 to 2mg percent within 6 hours;
after 12 hours practically no sulfonamide can be detected. Laboratory
studies with other species of animals have
demonstrated similar responses in