Држава: Канада
Језик: Енглески
Извор: Health Canada
CLONIDINE HYDROCHLORIDE
TEVA CANADA LIMITED
C02AC01
CLONIDINE
0.2MG
TABLET
CLONIDINE HYDROCHLORIDE 0.2MG
ORAL
100/500
Prescription
CENTRAL ALPHA-AGONISTS
Active ingredient group (AIG) number: 0108891002; AHFS:
CANCELLED PRE MARKET
2015-08-06
PRODUCT MONOGRAPH Pr NTP-CLONIDINE (Clonidine Hydrochloride) 0.1 and 0.2 mg Tablets USP Antihypertensive Teva Canada Ltd. 30 Novopharm Court Toronto, Ontario Canada, M1B 2K9 Submission Control No: 165993 Date of Preparation: July 17, 2013 PRODUCT MONOGRAPH NTP-CLONIDINE (Clonidine Hydrochloride) 0.1 and 0.2 mg Tablets USP THERAPEUTIC CLASSIFICATION Antihypertensive Agent ACTION AND CLINICAL PHARMACOLOGY Clinically, the principal effects seen with NTP-CLONIDINE (clonidine hydrochloride) are consistent with a direct action of the drug on the vasomotor centres in the brain stem. There is no blockade of peripheral ganglia, neurons or receptors. In animals, following clonidine administration, spontaneous sympathetic discharges from the medullary centres are reduced. A lowered tone of the vasomotor centres rather than blockade is suggested by the differential action on spontaneous and evoked central sympathetic impulses. Thus, clonidine has the ability to lower blood pressure while preserving normal homeostatic mechanisms. A pressor phase is not seen if the drug is given intramuscularly or orally, although with intravenous use of the drug a transient rise in blood pressure may precede the prolonged period of hypotension. The pressor phase following intravenous clonidine has been shown to be due to a direct effect of the drug on peripheral α-receptors, and this phase of the blood pressure effect and the depressor phase can be reversed by α-blocking drugs. It has been suggested therefore, that clonidine exerts an action on postulated central α-receptors in a manner similar to the action in the periphery. The prolonged hypotensive phase may thus result from two opposing actions each mediated by α-receptors. Effects on Catecholamines, Renin and Aldosterone: Tissue stores of catecholamines are not depleted by clonidine. However, as would be expected with central depression of sympathomimetic activity, clonidine therapy results in diminished urinary excretion of catecholamines. Conversely, there may be a sharp increase i Прочитајте комплетан документ