NORIT CAPSULE 200 mg ACTIVATED CHARCOAL

Country: Малезија

Језик: Енглески

Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активни састојак:

ACTIVATED CHARCOAL

Доступно од:

RX PHARMA SDN BHD

INN (Међународно име):

ACTIVATED CHARCOAL

Јединице у пакету:

30Capsule Capsules

Произведен од:

NORIT NEDERLAND B.V

Карактеристике производа

COMPOSITION: Each capsule contains 200
mg Activated Charcoal as active ingredient.
PRODUCT
DESCRIPTION:
Norit
capsules
contains activated charcoal which is a fine,
black, insoluble powder without taste or odor
in black hard gelatin capsule that has a unique
shorter and wider shape.
ROUTE OF ADMINSTRATION: Oral
PHARMACODYNAMICS:
Mechanism of Action: Activated charcoal is
obtained by destructive distillation of organic
material, coconut shells (which contain high
carbon content and low ash and tar content),
which are then ‘activated’ by exposing it to
oxidizing
STEAM
at
approximately
1000ºC
high
temperature
(in
depleted
oxygen
environment),
resulting
in
the
production
of
vastly
increased
surface
area
from
the
creation of pores (with controlled pore size).
The drug has the ability to adsorb a wide
variety of substances onto its surface. This
property can be applied in preventing the
absorption
of
various
harmful
substances,
which
are
responsible
for
diarrhea
cases
(traveler’s disease), from the gastrointestinal
tract
and
various
drugs
and
toxicants
involved with oral poisonings. Norit activated
charcoal
has
fulfilled
the
requirements
of
USA/
EUROPEAN
PHARMACOPOEIA
for
its
adsorption capacity of
≥
38% VS METHYLENE
BLUE and
≥ 40% PHENAZONE respectively (the
references test compounds in both respective
pharmacopoeia).
Adsorption of substances onto charcoal is
a reversible process with rapid adsorption
and slow resorption. The rate of adsorption
depends on the particle size, viscosity of the
medium, pH (acids and bases) and the amount
and type of gastrointestinal contents.
PHARMACOKINETICS:
Since
activated
charcoal
is
not
absorbed
from the gastro intestinal tract, there is no
distribution
phase
nor
any
metabolism.
The
complex
between
activated
carbon
and the adsorbed compounds may only be
passed in the stool. Norit activated charcoal
is compliance with ICH Q3D guidelines on
elemental impurities.
NORIT CAPSULE 200 MG
ACTIVATED CHARCOAL
INDICATIONS:
Norit is indicated as gastrointestinal absorbent
in the treatm