NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC ointment

Држава: Сједињене Америчке Државе

Језик: Енглески

Извор: NLM (National Library of Medicine)

Активни састојак:

NEOMYCIN SULFATE (UNII: 057Y626693) (NEOMYCIN - UNII:I16QD7X297)

Доступно од:

Lake Erie Medical DBA Quality Care Products LLC

INN (Међународно име):

NEOMYCIN SULFATE

Састав:

NEOMYCIN 3.5 mg in 1 g

Тип рецептора:

PRESCRIPTION DRUG

Статус ауторизације:

Abbreviated New Drug Application

Карактеристике производа

NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC- NEOMYCIN
SULFATE,
POLYMYXIN B SULFATE AND BACITRACIN ZINC OINTMENT
LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC
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NEOMYCIN AND POLYMYXIN B SULFATES AND
BACITRACIN ZINC OPHTHALMIC OINTMENT USP (STERILE)
RX ONLY
DESCRIPTION:
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic
Ointment USP is a sterile
antimicrobial ointment for ophthalmic use.
EACH GRAM CONTAINS:
ACTIVES: Neomycin Sulfate (equivalent to 3.5 mg neomycin base),
Polymyxin B Sulfate equivalent to
10,000 polymyxin B units, and Bacitracin Zinc equivalent to 400
bacitracin units; INACTIVES: White
Petrolatum, Mineral Oil.
Neomycin sulfate is the sulfate salt of neomycin B and C, which are
produced by the growth of
_Streptomyces fradiae _Waksman (Fam. Streptomycetaceae). It has a
potency equivalent of not less than 600
micrograms of neomycin standard per milligram, calculated on an
anhydrous basis. The structural
formulae are:
Polymyxin B sulfate is the sulfate salt of polymyxin B and B which are
produced by the growth of
_Bacillus polymyxa _(Prazmowski) Migula (Fam. Bacillaceae). It has a
potency of not less than 6,000
polymyxin B units per milligram, calculated on an anhydrous basis.
The structural formulae are:
Bacitracin zinc is the zinc salt of bacitracin, a mixture of related
cyclic polypeptides (mainly bacitracin
A) produced by the growth of an organism of the _licheniformis _group
of _Bacillus subtilis _var Tracy. It has
a potency of not less than 40 bacitracin units per milligram.
1
2
The structural formula for bacitracin A is:
CLINICAL PHARMACOLOGY:
A wide range of antibacterial action is provided by the overlapping
spectra of neomycin, polymyxin B
sulfate, and bacitracin.
Neomycin is bactericidal for many gram-positive and gram-negative
organisms. It is an aminoglycoside
antibiotic which inhibits protein synthesis by binding with ribosomal
RNA and causing misreading of
the bacterial genetic code.
Polymyxin B is bactericidal for a variety of gram-negative organisms.
It