MENDICOF SYRUP

Држава: Малезија

Језик: Енглески

Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активни састојак:

DEXCHLORPHENIRAMINE MALEATE; DEXTROMETHORPHAN; PSEUDOEPHEDRINE HYDROCHLORIDE

Доступно од:

SUNWARD PHARMACEUTICAL SDN. BHD.

INN (Међународно име):

DEXCHLORPHENIRAMINE MALEATE; DEXTROMETHORPHAN; PSEUDOEPHEDRINE HYDROCHLORIDE

Јединице у пакету:

120ml mL; 100ml mL; 60ml mL; 100 ml mL; 120 ml mL; 60 ml mL

Произведен од:

SUNWARD PHARMACEUTICAL SDN. BHD.

Карактеристике производа

Each 5ml contains:-
Dexchlorpheniramine Maleate
2mg
Pseudoephedrine HCI
30mg
Dextromethorphan HBr
15mg
PHARMACOLOGY:
Dextromethorphan HBr is a non-narcotic antitussive with effectiveness
equal to codeine. It acts in the medulla
oblongata to elevate the cough threshold. Dextromethorphan does not
produce analgesia or induce tolerance,
and has no potential for addiction. At usual doses, it will not
depress respiration or inhibit cilliary activity. It is
rapidly metabolised with trace amounts of parent compound in blood and
urine. After administration of
Dextromethorphan HBr 30mg by mouth to 6 subjects, the average plasma
concentration of its major
metabolites dextrophan and conjugates were about 21ng/ml after 15 min,
about 107ng/ml after 30 min and
about 368ng/ml after 60 min, with peak of about 381ng/ml after 2
hours.
Dexchlorpheniramine Maleate is an anti-histamine with anti-cholinergic
properties. It is capable of producing a
slight to moderate sedative effect. It appears to compete with
histamine for receptor sites on effector cells and
are of value clinically in the prevention and relief of many allergic
manifestations. It has been demonstrated
that the predominant activity of the optically active isomers of
chlorpheniramine is the dextro-isomer. The
dextro-isomer
is
approximately
two
times
more
active
than
the
racemic
compound.
Since
dexchlorpheniramine is the dextro-isomer and active moiety of
chlorpheniramine, its action and uses is similar
to those of chlorpheniramine.
Peak blood levels were achieved at an average time of 3 hours after
administration. The half life of
Dexchlorpheniramine Maleate ranged from 20 to 40 hours. The drug when
given is found to be extensively
metabolised. The drug and metabolites were primarily excreted in the
urine, with 19% of the dose appearing in
24 hours and total of 34% in 48 hours.
Pseudoephedrine is a physiologically active stereoisomer of ephedrine
that acts directly on alpha-adrenergic
receptors and to lesser degree, beta-adrenergic receptors. The
alpha-adrenergic effect