Country: Сједињене Америчке Државе
Језик: Енглески
Извор: NLM (National Library of Medicine)
FOSINOPRIL SODIUM (UNII: NW2RTH6T2N) (FOSINOPRILAT - UNII:S312EY6ZT8)
Lake Erie Medical DBA Quality Care Products LLC
FOSINOPRIL SODIUM
FOSINOPRIL SODIUM 20 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
FOSINOPRIL SODIUM- FOSINOPRIL SODIUM TABLET LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC ---------- FOSINOPRIL SODIUM TABLETS USE IN PREGNANCY WHEN USED IN PREGNANCY DURING THE SECOND AND THIRD TRIMESTERS, ACE INHIBITORS CAN CAUSE INJURY AND EVEN DEATH TO THE DEVELOPING FETUS. When pregnancy is detected, fosinopril sodium should be discontinued as soon as possible. See WARNINGS, FETAL/NEONATAL MORBIDITY AND MORTALITY . DESCRIPTION Fosinopril sodium tablets are the sodium salt of fosinopril, the ester prodrug of an angiotensin- converting enzyme (ACE) inhibitor, fosinoprilat. It contains a phosphinate group capable of specific binding to the active site of angiotensin-converting enzyme. Fosinopril sodium is designated chemically as: L-proline, 4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy)propoxy](4- phenylbutyl)phosphinyl]acetyl]-, sodium salt, _trans-_. Fosinopril sodium USP is a white to off-white crystalline powder. It is soluble in water (100 mg/mL), methanol, and ethanol and slightly soluble in hexane. Its structural formula is: Empirical formula: C H NNaO P Molecular weight: 585.65 Fosinopril Sodium is available for oral administration as 10 mg, 20 mg, and 40 mg tablets. Inactive ingredients include: lactose, microcrystalline cellulose, carnauba wax, crospovidone, and zinc stearate. CLINICAL PHARMACOLOGY MECHANISM OF ACTION In animals and humans, fosinopril sodium is hydrolyzed by esterases to the pharmacologically active form, fosinoprilat, a specific competitive inhibitor of angiotensin-converting enzyme (ACE). ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase of 30 45 7 serum potassium. In 647 hypertensive patients treated with fosinopril alone for an average Прочитајте комплетан документ