FLUIMUCIL GRANULES 600mgsachet

Country: Сингапур

Језик: Енглески

Извор: HSA (Health Sciences Authority)

Активни састојак:

Acetylcysteine

Доступно од:

UNITED ITALIAN TRADING CORPORATION (PRIVATE) LIMITED

АТЦ код:

R05CB01

Фармацеутски облик:

GRANULE, FOR SOLUTION

Састав:

Acetylcysteine 600mg

Пут администрације:

ORAL

Тип рецептора:

Pharmacy Only

Произведен од:

Zambon Switzerland Ltd.

Статус ауторизације:

ACTIVE

Датум одобрења:

2016-12-29

Информативни летак

H02V201
E03.1116
BLACK U
FI 506: 135x280 mm
1/1 B
CHARACTERISTICS
Acetylcysteine (NAC), the active ingredient of
FLUIMUCIL
®
A Effervescent Tablet 600mg and
Fluimucil
®
Granules 600mg, exerts an intense
mucolytic action on mucous and mucopurulent
secretions, by depolymerizing the mucoproteic
complexes and the nucleic acids which confer
viscosity to the vitreous and purulent component
of the sputum and of other secretions. Further-
more, NAC, exerts a direct antioxidant action,
being provided with a free thiol (-SH nucleophilic)
group, which is able to interact directly with the
electrophilic groups of the oxidant radicals. Of
particular interest is the recent demonstration that
NAC protects the
∝
-1-antitrypsin, enzyme inhib-
itor of elastase, from the inactivation due to the
action of hypochlorous acid (HOCI), a powerful
oxidant agent produced by the myeloperoxidase
enzyme of activated phagocytes. These features
make FLUIMUCIL
®
A Effervescent Tablet 600mg
and Fluimucil
®
Granules 600mg particularly suit-
able for the treatment of acute and chronic af-
fections of the respiratory system, characterized
by thick and viscous mucous and mucopurulent
secretions.
Furthermore,
the
molecular
struc-
ture permits the molecule to cross easily cellular
membranes. Inside the cell, NAC is deacetylized,
forming L-cysteine, an amino acid indispensa-
ble for the glutathione synthesis (GSH). GSH is
a highly reactive tripeptide, found ubiquitously
in the various tissues of animals and is essential
for the maintenance of functional capacity as
well as cellular morphological integrity, as it rep-
resents the most important protective, endocel-
lular mechanism against oxidant radicals, either
of external or internal nature. As well as towards
numerous cytotoxic substances. NAC plays a
role of primary importance in the maintenance
of adequate GSH levels thus contributing to the
cellular protections from harmful agents which,
through progressive GSH depletion, would be
able to express their cytotoxic actions, as in the
case of ac

Карактеристике производа

_Package Leaflet _
_ _
FLUIMUCIL® A 600 EFFERVESCENT TABLETS 600MG
FLUIMUCIL® GRANULES 600MG/SACHET
FOR ORAL USE PHARMACOLOGICAL PROPERTIES
Acetylcysteine (NAC), the active ingredient of Fluimucil® A
Effervescent Tablets 600mg and
Fluimucil® Granules 600mg exerts an intense
mucolytic-fluidifying
action on mucous and
mucopurulent secretions, by depolymerizing the mucoproteic complexes
and the nucleic
acids which confer viscosity to the vitreous and purulent component of
the sputum and of
other secretions.
Additional properties are: reduction of induced hyperplasia of mucous
cells, increase in
surfactant production by stimulation of type II pneumocytes,
stimulation of mucociliary
activity, leading to improved mucociliary clearance.
Furthermore, NAC, exerts a direct antioxidant action, being provided
with a free thiol (-SH
nucleophilic) group, which is able to interact directly with the
electrophilic groups of the
oxidant radicals. Of particular interest is the finding that NAC
protects the
∝
-1-antitrypsin,
enzyme inhibitor of elastase, from the inactivation due to the action
of hypochlorous acid
(HOCI), a powerful oxidant agent produced by the myeloperoxidase
enzyme of activated
phagocytes.
Furthermore,
Acetylcysteine exerts in addition an indirect antioxidant effect
through its role as GSH precursor
. Inside the cell, NAC is deacetylized, forming L-cysteine, an
amino acid indispensable for the glutathione synthesis (GSH). GSH is a
highly reactive
tripeptide, found ubiquitously in the various tissues of animals and
is essential for the
maintenance
of
functional
capacity
as
well
as
cellular
morphological
integrity,
as
it
represents the most important protective endocellular mechanism
against oxidant radicals,
either of external or internal nature, as well as towards numerous
cytotoxic substances.
NAC plays a role of primary importance in the maintenance of adequate
GSH levels thus
contributing to the cellular protections from harmful agents which,
through progressive GSH
depletion, would be able to express th