Држава: Малезија
Језик: Енглески
Извор: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CARPROFEN
Rhone Ma Malaysia Sdn Bhd
CARPROFEN
100tablet Tablets
Chanelle Pharmaceuticals Manufacturing Limited
VERSION: 5 MMM/YY: XXX GMP COMPOSITION: ONE GRILLED MEAT FLAVOURED TABLET CONTAINS: ACTIVE INGREDIENT Carprofen 20.0 mg/tablet, Carprofen 50.0 mg/tablet, Carprofen 100.0 mg/tablet. PRODUCT DESCRIPTION: Canidryl 20mg & 50mg : A plain round flat bevelled edge tablet, white to off-white flavoured tablet with a breakline on one side. Canidryl 100mg : A white to off-white round shape flavoured tablet with a cross break line on one side. The tablets can be divided into equal halves or quaters. PHARMACODYNAMICS: Carprofen is a member of the 2-arylpropionic acid group of non-steroidal anti-inflammatory drugs (NSAIDs), and possesses anti-inflammatory, analgesic and antipyretic activity. Carprofen is a chiral drug with the S(+) enantiomer being more active than the R(-) enantiomer. Carprofen, like most other NSAIDs is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action of carprofen is not clear. PHARMACOKINETICS: After oral administration, carprofen is well absorbed in the dogs. Following the administration of Canidryl tablets in dogs, a mean Cmax (maximum concentration in serum) of 15.8 µg/ml and 12.2 µg/ml was achieved at approximately 2 hours and 1.7 hours for Carprofen R(-) and Carprofen S(+), respectively. For both enantiomers, the mean half-life was approximately 6 hours. The analgesic effect from each dose persists for at least 12 hours. Carprofen has a small volume of distribution and a low systemic clearance. It is highly bound to plasma protein. Carprofen is metabolised in the liver by conjugation and oxidation. The excretion of the glycuronide conjugate is mainly faecal after biliary excretion. INDICATION: _ In the dog:_ Reduction of inflammation and pain caused by musculo-skeletal disorders and degenerative joint disease. As a follow up to parenteral analgesia in the management of post-operative pain following soft tissue surge Прочитајте комплетан документ