Држава: Аустралија
Језик: Енглески
Извор: Department of Health (Therapeutic Goods Administration)
Azathioprine
Sandoz Pty Ltd
Medicine Registered
Azathioprine Sandoz 1 AZATHIOPRINE SANDOZ _ _ AZATHIOPRINE FILM-COATED TABLETS_ _ CONSUMER MEDICINE INFORMATION _ _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Azathioprine Sandoz. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking this medicine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT AZATHIOPRINE SANDOZ IS USED FOR This medicine is used to prevent the body from rejecting transplanted organs. Azathioprine Sandoz can also be used to treat diseases involving the body’s immune defence system such as: _ _ severe rheumatoid arthritis systemic lupus erythematosus (SLE) chronic active hepatitis certain skin, muscle and blood diseases. It contains the active ingredient azathioprine._ _ Azathioprine belongs to a group of medicines called immunosuppressants. _ _ It works by reducing the body’s own natural immunity._ _ ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is not addictive. This medicine is available only with a doctor’s prescription. _ _ BEFORE YOU TAKE AZATHIOPRINE SANDOZ _WHEN YOU MUST NOT TAKE IT _ DO NOT TAKE THIS MEDICINE IF YOU HAVE AN ALLERGY TO: azathioprine, the active ingredient, or to any of the other ingredients listed at the end of this leaflet under Product Description Azathioprine Sandoz 2 any other similar medicines such Прочитајте комплетан документ
_Product Information _ _ _ _Page 1 of 13 _ _Azathioprine Sandoz 25mg & 50mg film coated tablets _ _Sandoz Pty Ltd _ PRODUCT INFORMATION AZATHIOPRINE SANDOZ 25MG AND 50MG TABLETS NAME OF THE MEDICINE Azathioprine 6-[(1-methyl-4-nitro-1-H-imidazol-5-yl)thio]-1-H-purine CAS [446-86-6] Empirical formula: C 9 H 7 N 7 O 2 S MW: 277.3 DESCRIPTION A pale-yellow powder, practically insoluble in water and in alcohol. It is soluble in dilute solutions of alkali hydroxides and sparingly soluble in dilute mineral acids. In addition to azathioprine, Azathioprine Sandoz film-coated tablets contain: lactose, maize starch, povidone, colloidal anhydrous silica, magnesium stearate, hypromellose, microcrystalline cellulose, PEG-8 stearate, talc, titanium dioxide. PHARMACOLOGY Pharmacodynamics Azathioprine is an immuno-suppressive antimetabolite. Azathioprine is an imidazole derivative of 6-mercaptopurine (6-MP). It is rapidly broken down in vivo into 6-MP and a methylnitroimidazole moiety. The 6-MP readily crosses cell membranes and is converted intracellularly into a number of purine thioanalogues, which include the main active nucleotide, thioinosinic acid. The rate of conversion varies from one person to another. Nucleotides do not traverse cell membranes and therefore do not circulate in body fluids. Irrespective of whether it is given directly or is derived in vivo from azathioprine, 6-MP is eliminated mainly as the inactive oxidised metabolite thiouric acid. This oxidation is brought about by xanthine oxidase, an enzyme which is inhibited by allopurinol. The activity of the methylnitroimida Прочитајте комплетан документ